The use of therapeutic exosomes for in vivo wound healing.

IF 3.2 4区医学 Q3 CELL & TISSUE ENGINEERING

Cell Transplantation Pub Date : 2026-01-01 Epub Date: 2026-02-20 DOI:10.1177/09636897261418580

Elena Bigliardi, Paul Bigliardi, Julianna Goenaga, Nikhil Iyer, Dilmareth Natera-Rodriguez, Madison B Waldron, Walter C Low, Mei Bigliardi-Qi

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引用次数: 0

Abstract

Normal wound healing is a complex, yet critical process. Unfortunately, delayed or impaired wound healing presents a significant burden for numerous patients worldwide. Recent research has demonstrated that exosomes, a subtype of extracellular vesicles, may play a pivotal role in mediating cell-cell communication during wound healing. This narrative review aims to explore the use of exosomes in wound healing, with a focus on in vivo application of exosomes in animal wound models. A total of 73 studies are outlined in this narrative review, exploring either excisional, diabetic, burn, ischemic, or pressure wounds. Overall, the most frequent source of exosomes was adipose-derived mesenchymal stem cells, and the most common application method was local or subcutaneous injection. While these studies demonstrated great promise for the use of exosomes for therapeutic use in wound healing, this review also discusses the challenges and obstacles that will need to be overcome, including standardizing methods, further characterizing exosomes and identifying the optimal sources and doses in the development of exosome therapies.

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治疗性外泌体在体内伤口愈合中的应用。

正常的伤口愈合是一个复杂而又关键的过程。不幸的是，伤口愈合延迟或受损给全世界许多患者带来了沉重的负担。最近的研究表明，外泌体是细胞外囊泡的一种亚型，可能在伤口愈合过程中介导细胞间通讯中起关键作用。本文旨在探讨外泌体在伤口愈合中的应用，重点介绍外泌体在动物伤口模型中的体内应用。本文综述了73项研究，探讨了切除、糖尿病、烧伤、缺血性或压伤。总的来说，外泌体最常见的来源是脂肪来源的间充质干细胞，最常见的应用方法是局部或皮下注射。虽然这些研究显示了外泌体在伤口愈合治疗中的巨大前景，但本综述也讨论了需要克服的挑战和障碍，包括标准化方法，进一步表征外泌体，确定外泌体治疗发展的最佳来源和剂量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Transplantation 生物-细胞与组织工程

CiteScore

6.00

自引率

3.00%

发文量

审稿时长

6 months

期刊介绍： Cell Transplantation, The Regenerative Medicine Journal is an open access, peer reviewed journal that is published 12 times annually. Cell Transplantation is a multi-disciplinary forum for publication of articles on cell transplantation and its applications to human diseases. Articles focus on a myriad of topics including the physiological, medical, pre-clinical, tissue engineering, stem cell, and device-oriented aspects of the nervous, endocrine, cardiovascular, and endothelial systems, as well as genetically engineered cells. Cell Transplantation also reports on relevant technological advances, clinical studies, and regulatory considerations related to the implantation of cells into the body in order to provide complete coverage of the field.