Psychological features and quality of life in low-dose CT lung cancer screening: a comparative analysis with general population data

IF 5.3 2区医学 Q1 ONCOLOGY

Lung Cancer Pub Date : 2026-03-01 Epub Date: 2026-02-03 DOI:10.1016/j.lungcan.2026.109307

Wei-Chia Huang , Tzu-Ning Kao , Shih-Cheng Liao , Mong-Wei Lin , Wei-Lieh Huang

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引用次数: 0

Abstract

Objective

Concerns persist regarding the psychological effects of low dose computed tomography (LDCT) screening, with prior studies linking it to psychological distress and diminished quality of life (QoL). However, specific risk factors remain unclear. This study aimed to compare the psychological features of LDCT recipients with the general population and identify associated factors.

Methods

A cross-sectional analysis was conducted using prospectively collected data from April 2022 to April 2023. Participants seeking second opinions at a tertiary medical center in Asia after LDCT screenings were recruited. We collected sociodemographic data, screening details, and self-administered questionnaires assessing somatic symptoms, health anxiety, depression, anxiety, and quality of life. Psychological conditions and QoL were compared between LDCT recipients and a general population cohort comprising 3161 individuals.

Results

We compared 201 LDCT recipients (30.8% male, mean age 56.6 years) with 3161 general population controls. Compared to the general population (adjusted for age and sex), LDCT recipients had significantly higher rates of somatic symptom disorder (28.9% vs. 5.0%, p < 0.001), depression (16.4% vs. 5.7%, p < 0.001), and anxiety (20.9% vs. 3.5%, p < 0.001). Among 103 participants undergoing surgical intervention, 85.4% were diagnosed with malignant or precancerous lesions. The 3-year overall survival rate was 98.0%, indicating favorable clinical outcomes.

Conclusion

LDCT recipients in an Asian population exhibited a higher prevalence of psychological distress than the general population. Close monitoring is essential, especially among those with pre-existing mental health issues. Future longitudinal studies are needed to elucidate long-term psychological outcomes of LDCT screening.

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低剂量CT肺癌筛查的心理特征和生活质量：与普通人群数据的比较分析。

目的：低剂量计算机断层扫描（LDCT）筛查对心理的影响一直受到关注，之前的研究将其与心理困扰和生活质量（QoL）下降联系起来。然而，具体的风险因素仍不清楚。本研究旨在比较LDCT受者与一般人群的心理特征，并确定相关因素。方法：对2022年4月至2023年4月前瞻性收集的数据进行横断面分析。招募了在亚洲三级医疗中心接受LDCT筛查后寻求第二意见的参与者。我们收集了社会人口统计数据、筛选细节和自我管理的问卷，评估躯体症状、健康焦虑、抑郁、焦虑和生活质量。比较LDCT接受者和3161名普通人群的心理状况和生活质量。结果：我们比较了201例LDCT受者（30.8%为男性，平均年龄56.6岁）和3161例普通人群对照。与普通人群相比（根据年龄和性别进行调整），LDCT受者的躯体症状障碍发生率明显更高（28.9% vs. 5.0%）， p结论：亚洲人群中LDCT受者的心理困扰患病率高于普通人群。密切监测至关重要，特别是对那些已经存在精神健康问题的人。未来的纵向研究需要阐明LDCT筛查的长期心理结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lung Cancer 医学-呼吸系统

CiteScore

9.40

自引率

3.80%

发文量

407

审稿时长

25 days

期刊介绍： Lung Cancer is an international publication covering the clinical, translational and basic science of malignancies of the lung and chest region.Original research articles, early reports, review articles, editorials and correspondence covering the prevention, epidemiology and etiology, basic biology, pathology, clinical assessment, surgery, chemotherapy, radiotherapy, combined treatment modalities, other treatment modalities and outcomes of lung cancer are welcome.