{"title":"Time-Course Changes in Biomarker Levels Observed in Effluent of Patients Administered Bicarbonate/Lactate-Buffered Neutral-pH Peritoneal Dialysis Fluid.","authors":"Risa Terashima, Nanae Matsuo, Yudo Tanno, Yukio Maruyama, Ichiro Ohkido, Takashi Yokoo","doi":"10.1159/000550321","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Biomarker levels in peritoneal dialysis (PD) effluent can predict the risks of inflammation, wasting, atherosclerosis, encapsulating peritoneal sclerosis, and mortality. However, assessments of biomarker variations associated with different dwell times and buffered solutions have yielded inconsistent results.</p><p><strong>Methods: </strong>This prospective crossover study examined 10 patients on PD to investigate changes in effluent biomarkers during a retention period of 8 h. Biomarker concentrations in bicarbonate lactate-buffered neutral-pH PD fluid (Bic/Lac PDF) effluent and those in lactate-buffered neutral-pH PD fluid (Lac PDF) effluent were compared.</p><p><strong>Results: </strong>Concentrations of urea nitrogen, creatinine, β2-microglobulin, and α1-microglobulin associated with Bic/Lac PDF and Lac PDF did not differ (analysis of variance [ANOVA]: p = 0.62, 0.25, 0.73, and 0.95, respectively). Differences in cancer antigen 125, interleukin-6, fibrin degradation products (FDP), vascular endothelial growth factor (VEGF), and tumor necrosis factor-α (TNF-α) were not observed (ANOVA: p = 0.81, 0.72, 0.66, 0.87, and 0.94, respectively). Additionally, concentrations of these biomarkers gradually increased over time from the start of PDF infusion until 8 h later; however, in some cases, FDP, VEGF, and TNF-α concentrations in effluent were below the detection limits at 2, 4, 6, and 8 h.</p><p><strong>Conclusion: </strong>A protective effect of Bic/Lac PDF on the peritoneal membrane was not observed. Biomarker concentrations in PD effluent gradually increased over time; however, some were below the detection limits during 8 h of retention. Assessments of biomarkers in effluent should be performed after an extended dwell time.</p>","PeriodicalId":8953,"journal":{"name":"Blood Purification","volume":" ","pages":"315-322"},"PeriodicalIF":2.2000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Blood Purification","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000550321","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/2/10 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Biomarker levels in peritoneal dialysis (PD) effluent can predict the risks of inflammation, wasting, atherosclerosis, encapsulating peritoneal sclerosis, and mortality. However, assessments of biomarker variations associated with different dwell times and buffered solutions have yielded inconsistent results.
Methods: This prospective crossover study examined 10 patients on PD to investigate changes in effluent biomarkers during a retention period of 8 h. Biomarker concentrations in bicarbonate lactate-buffered neutral-pH PD fluid (Bic/Lac PDF) effluent and those in lactate-buffered neutral-pH PD fluid (Lac PDF) effluent were compared.
Results: Concentrations of urea nitrogen, creatinine, β2-microglobulin, and α1-microglobulin associated with Bic/Lac PDF and Lac PDF did not differ (analysis of variance [ANOVA]: p = 0.62, 0.25, 0.73, and 0.95, respectively). Differences in cancer antigen 125, interleukin-6, fibrin degradation products (FDP), vascular endothelial growth factor (VEGF), and tumor necrosis factor-α (TNF-α) were not observed (ANOVA: p = 0.81, 0.72, 0.66, 0.87, and 0.94, respectively). Additionally, concentrations of these biomarkers gradually increased over time from the start of PDF infusion until 8 h later; however, in some cases, FDP, VEGF, and TNF-α concentrations in effluent were below the detection limits at 2, 4, 6, and 8 h.
Conclusion: A protective effect of Bic/Lac PDF on the peritoneal membrane was not observed. Biomarker concentrations in PD effluent gradually increased over time; however, some were below the detection limits during 8 h of retention. Assessments of biomarkers in effluent should be performed after an extended dwell time.
期刊介绍：
Practical information on hemodialysis, hemofiltration, peritoneal dialysis and apheresis is featured in this journal. Recognizing the critical importance of equipment and procedures, particular emphasis has been placed on reports, drawn from a wide range of fields, describing technical advances and improvements in methodology. Papers reflect the search for cost-effective solutions which increase not only patient survival but also patient comfort and disease improvement through prevention or correction of undesirable effects. Advances in vascular access and blood anticoagulation, problems associated with exposure of blood to foreign surfaces and acute-care nephrology, including continuous therapies, also receive attention. Nephrologists, internists, intensivists and hospital staff involved in dialysis, apheresis and immunoadsorption for acute and chronic solid organ failure will find this journal useful and informative. ''Blood Purification'' also serves as a platform for multidisciplinary experiences involving nephrologists, cardiologists and critical care physicians in order to expand the level of interaction between different disciplines and specialities.
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