Mandibular-morphogenesis gene linked to the H-2 complex in mice.

Abstract

The shapes of mandibles from mice of a group of H-2 congenic strains are compared to that of their C57BL/6By background strain. One congenic strain carries a passenger gene that evokes an elongation of the dorsal reach of the condylar process as does an H-2 recombinant congenic strain derived from it. Two other independently derived H-2 congenic strains do not carry such a gene. This indicates that the effective gene resides outside of and on the centromeric side of the H-2 complex on chromosome 17. Reiterated tests demonstrate the reproducibility of this type of genetic analysis.