The effects of coenzyme Q10 supplementation on glycemic control in diabetic and non-diabetic individuals: a systematic review and meta-analysis.

IF 10.6 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Critical reviews in food science and nutrition Pub Date : 2026-01-01 Epub Date: 2026-02-02 DOI:10.1080/10408398.2026.2624477

Lucas das Neves Collares, Gabriel Peres Messenburger, Fernanda Ferreira Nuñez, Simone Pieniz

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引用次数: 0

Abstract

Background & aims: Type 2 diabetes mellitus (T2DM) is a global concern characterized by insulin resistance and impaired insulin secretion. Coenzyme Q10 (CoQ10), a mitochondrial cofactor with antioxidant properties, has been investigated for its potential role in glycemic regulation. This systematic review and meta-analysis evaluated the effects of oral CoQ10 supplementation on glycemic control markers in adults with and without T2DM.

Methods: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to assess the effects of CoQ10 supplementation on fasting blood glucose (FBG), glycated hemoglobin (HbA1c), and fasting insulin. Subgroup analyses were conducted according to population type, dosage, and duration of intervention. Study quality and certainty of evidence were assessed using the Cochrane RoB 2.0 tool and the GRADE approach.

Results: Thirty-nine RCTs were included. CoQ10 supplementation was associated with modest but statistically significant reductions in FBG (-7.33 mg/dL; 95% CI: -10.67 to -3.99), HbA1c (-0.12%; 95% CI: -0.28 to 0.03), and fasting insulin (-0.84 μIU/mL; 95% CI: -1.18 to -0.49) compared to placebo.

Conclusion: CoQ10 supplementation may produce small improvements in glycemic markers, especially in individuals with T2DM. However, due to very low certainty of evidence, findings should be interpreted cautiously until confirmed by high-quality studies.

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补充辅酶Q10对糖尿病和非糖尿病患者血糖控制的影响：一项系统综述和荟萃分析

背景与目的：2型糖尿病（T2DM）是一种以胰岛素抵抗和胰岛素分泌受损为特征的全球性疾病。辅酶Q10 （CoQ10）是一种具有抗氧化特性的线粒体辅助因子，已被研究其在血糖调节中的潜在作用。本系统综述和荟萃分析评估了口服辅酶q10补充剂对有和无T2DM成人血糖控制指标的影响。方法：对随机对照试验（rct）进行系统回顾和荟萃分析，以评估补充辅酶q10对空腹血糖（FBG）、糖化血红蛋白（HbA1c）和空腹胰岛素的影响。根据人群类型、剂量和干预时间进行亚组分析。使用Cochrane RoB 2.0工具和GRADE方法评估研究质量和证据的确定性。结果：纳入39项随机对照试验。与安慰剂相比，辅酶q10补充与空腹血糖（-7.33 mg/dL; 95% CI: -10.67至-3.99）、糖化血红蛋白（-0.12%;95% CI: -0.28至0.03）和空腹胰岛素（-0.84 μIU/mL; 95% CI: -1.18至-0.49）的适度但具有统计学意义的降低相关。结论：补充辅酶q10可能会对血糖指标产生微小的改善，特别是在T2DM患者中。然而，由于证据的确定性非常低，在得到高质量研究的证实之前，研究结果应谨慎解释。

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来源期刊

Critical reviews in food science and nutrition 工程技术-食品科技

CiteScore

22.60

自引率

4.90%

发文量

600

审稿时长

7.5 months

期刊介绍： Critical Reviews in Food Science and Nutrition serves as an authoritative outlet for critical perspectives on contemporary technology, food science, and human nutrition. With a specific focus on issues of national significance, particularly for food scientists, nutritionists, and health professionals, the journal delves into nutrition, functional foods, food safety, and food science and technology. Research areas span diverse topics such as diet and disease, antioxidants, allergenicity, microbiological concerns, flavor chemistry, nutrient roles and bioavailability, pesticides, toxic chemicals and regulation, risk assessment, food safety, and emerging food products, ingredients, and technologies.