Effect of different exercise types on physical function and psychological status in females with multiple sclerosis: A network meta-analysis

IF 3 3区医学 Q2 CLINICAL NEUROLOGY

Multiple sclerosis and related disorders Pub Date : 2026-04-01 Epub Date: 2026-01-29 DOI:10.1016/j.msard.2026.107036

Yutong Wang , Liang Li , Chen Liu , Tonggang Fan

{"title":"Effect of different exercise types on physical function and psychological status in females with multiple sclerosis: A network meta-analysis","authors":"Yutong Wang , Liang Li , Chen Liu , Tonggang Fan","doi":"10.1016/j.msard.2026.107036","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>As a therapeutic approach, physical activity can serve as a rehabilitation method for females with multiple sclerosis. However, the optimal exercise type remains unclear. This study aims to evaluate the effects of six distinct training programs on the physical function and psychological state of females with multiple sclerosis, thereby providing foundational guidance for rehabilitation treatment in this population.</div></div><div><h3>Method</h3><div>In September 2025, a comprehensive literature search was conducted across seven major databases (Embase, PubMed, Web of Science, Cochrane Library, Wanfang, CNKI, and CQVIP) to identify randomized controlled trials to study how physical activity interventions affect the physical function and psychological status in females with multiple sclerosis. These studies were subsequently analyzed through a frequency-based network meta-analysis framework.</div></div><div><h3>Results</h3><div>We conducted a systematic review analyzing 16 studies involving 579 participants. Among the six exercise modalities tested in the intervention groups, all demonstrated statistically significant efficacy compared to the control groups. However, pairwise comparisons between different exercise categories revealed minimal differences. Using the surface under the cumulative ranking curve (SUCRA) metric, researchers evaluated and ranked the impact of these interventions on both physical function and psychological status in females multiple sclerosis, FATIGUE: Yoga (SUCRA=81) > RE (SUCRA=77) > AE (SUCRA=67.6) > CE (SUCRA=56.0) > CT (SUCRA=30.8) > MBE (SUCRA=25.7) > RT(SUCRA=11.9); QoL-total: RE (SUCRA=69.7) > AE (SUCRA=63.5) > Yoga (SUCRA=63.0) > RT (SUCRA=3.9); BALANCE: AE (SUCRA=89.7) > Yoga (SUCRA=66.9) > MBE (SUCRA=55.0) > RE (SUCRA=36.7) > RT (SUCRA=1.7); Qol-ph: MBE(SUCRA=82.0) > Yoga (SUCRA=78.7) > AE (SUCRA=45.1) > CE (SUCRA=35.8) > RT (SUCRA= 8.5); DEPRESS: Yoga (SUCRA=74.6) > AE (SUCRA=66.3) > CT (SUCRA=53.0) > CE (SUCRA=49.9) > MBE (SUCRA=45.6) > RT (SUCRA=10.6), Qol-mh: Yoga (SUCRA=79.5) > MBE (SUCRA=68.5) > CE (SUCRA=53.9) > AE (SUCRA=46.4) > RT (SUCRA=1.8).</div></div><div><h3>Conclusions</h3><div>For females with multiple sclerosis, regular physical activity boosts physical function and psychological status outcomes. Among these activities, yoga is the most effective way to improve their psychological well-being.</div></div>","PeriodicalId":18958,"journal":{"name":"Multiple sclerosis and related disorders","volume":"108 ","pages":"Article 107036"},"PeriodicalIF":3.0000,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Multiple sclerosis and related disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211034826000726","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/29 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

As a therapeutic approach, physical activity can serve as a rehabilitation method for females with multiple sclerosis. However, the optimal exercise type remains unclear. This study aims to evaluate the effects of six distinct training programs on the physical function and psychological state of females with multiple sclerosis, thereby providing foundational guidance for rehabilitation treatment in this population.

Method

In September 2025, a comprehensive literature search was conducted across seven major databases (Embase, PubMed, Web of Science, Cochrane Library, Wanfang, CNKI, and CQVIP) to identify randomized controlled trials to study how physical activity interventions affect the physical function and psychological status in females with multiple sclerosis. These studies were subsequently analyzed through a frequency-based network meta-analysis framework.

Results

We conducted a systematic review analyzing 16 studies involving 579 participants. Among the six exercise modalities tested in the intervention groups, all demonstrated statistically significant efficacy compared to the control groups. However, pairwise comparisons between different exercise categories revealed minimal differences. Using the surface under the cumulative ranking curve (SUCRA) metric, researchers evaluated and ranked the impact of these interventions on both physical function and psychological status in females multiple sclerosis, FATIGUE: Yoga (SUCRA=81) > RE (SUCRA=77) > AE (SUCRA=67.6) > CE (SUCRA=56.0) > CT (SUCRA=30.8) > MBE (SUCRA=25.7) > RT(SUCRA=11.9); QoL-total: RE (SUCRA=69.7) > AE (SUCRA=63.5) > Yoga (SUCRA=63.0) > RT (SUCRA=3.9); BALANCE: AE (SUCRA=89.7) > Yoga (SUCRA=66.9) > MBE (SUCRA=55.0) > RE (SUCRA=36.7) > RT (SUCRA=1.7); Qol-ph: MBE(SUCRA=82.0) > Yoga (SUCRA=78.7) > AE (SUCRA=45.1) > CE (SUCRA=35.8) > RT (SUCRA= 8.5); DEPRESS: Yoga (SUCRA=74.6) > AE (SUCRA=66.3) > CT (SUCRA=53.0) > CE (SUCRA=49.9) > MBE (SUCRA=45.6) > RT (SUCRA=10.6), Qol-mh: Yoga (SUCRA=79.5) > MBE (SUCRA=68.5) > CE (SUCRA=53.9) > AE (SUCRA=46.4) > RT (SUCRA=1.8).

Conclusions

For females with multiple sclerosis, regular physical activity boosts physical function and psychological status outcomes. Among these activities, yoga is the most effective way to improve their psychological well-being.

查看原文本刊更多论文

不同运动类型对多发性硬化症女性身体功能和心理状态的影响：网络荟萃分析

作为一种治疗方法，体育活动可以作为多发性硬化症女性患者的康复方法。然而，最佳的运动类型仍然不清楚。本研究旨在评价6种不同训练方案对多发性硬化症女性患者身体功能和心理状态的影响，从而为该人群的康复治疗提供基础指导。方法于2025年9月，在Embase、PubMed、Web of Science、Cochrane Library、万方、CNKI、CQVIP等7大数据库中进行文献检索，筛选随机对照试验，研究体育活动干预对多发性硬化症女性身体功能和心理状态的影响。这些研究随后通过基于频率的网络元分析框架进行分析。结果我们对16项涉及579名参与者的研究进行了系统回顾分析。在干预组测试的六种运动方式中，与对照组相比，均显示出统计学上显著的疗效。然而，不同运动类别之间的两两比较显示差异很小。采用累积排序曲线下曲面（SUCRA）指标，研究人员评估了这些干预措施对女性多发性硬化症身体功能和心理状态的影响，并对其进行了排序：FATIGUE：瑜伽（SUCRA=81） > RE (SUCRA=77) > AE (SUCRA=67.6) > CE (SUCRA=56.0) > CT (SUCRA=30.8) > MBE (SUCRA=25.7) >； RT(SUCRA=11.9)；ql -total: RE (SUCRA=69.7) > AE (SUCRA=63.5) > Yoga (SUCRA=63.0) > RT (SUCRA=3.9)；平衡：AE (SUCRA=89.7) > Yoga (SUCRA=66.9) > MBE (SUCRA=55.0) > RE (SUCRA=36.7) > RT (SUCRA=1.7)；ql -ph: MBE(SUCRA=82.0) > Yoga (SUCRA=78.7) > AE (SUCRA=45.1) > CE (SUCRA=35.8) > RT (SUCRA= 8.5)；抑郁症：瑜伽（SUCRA=74.6） > AE (SUCRA=66.3) > CT (SUCRA=53.0) > CE (SUCRA=45.6) > RT (SUCRA=10.6)， ql -mh：瑜伽（SUCRA=79.5） > MBE (SUCRA=68.5) > CE (SUCRA=53.9) > AE (SUCRA=46.4) > RT （SUCRA=1.8）。结论对于多发性硬化症女性患者，规律的体育锻炼可改善身体功能和心理状况。在这些活动中，瑜伽是改善他们心理健康的最有效的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.