A new effective treatment for dyslexia based on dorsal visual stream neuromodulation.

IF 3.6 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Neurodevelopmental Disorders Pub Date : 2026-01-31 DOI:10.1186/s11689-026-09675-3

Giuseppe Di Dona, Denisa Adina Zamfira, Francesco De Benedetto, Chiara Turri, Camilla Venturini, Lisa Venniro, Daniela Perani, Luca Ronconi

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引用次数: 0

Abstract

Developmental dyslexia (DD) affects approximately 10% of individuals, impairing reading ability thus limiting professional fulfilment and psychological wellbeing. DD is associated with both phonological and visual deficits, and the latter are attributed to dysfunctions of the magnocellular-dorsal visual stream, which has a critical role in planning saccades and supporting the extraction of letters/words identity. Currently, there are no effective treatments to restore the brain networks underlying visuospatial analysis and oculomotor efficiency. Adults with DD were enrolled in a randomised clinical trial introducing a non-invasive neuromodulation protocol specifically designed to enhance dorsal stream functionality. We used bi-focal beta-band transcranial alternating current stimulation (tACS) in parietal areas, due to the recognized role of beta oscillation in the dorsal stream functionality. Coupled with a 12-session visuoattentional training, such protocol induced improvements in reading speed, oculomotor control, and visual motion perception. Additionally, beta-tACS led to long-term enhancement of working memory. These outcomes were exclusive or superior to those obtained with a placebo/sham neuromodulation, and were accompanied by plastic changes in the stimulated brain networks. Overall, our findings show the efficacy of multisession tACS in improving core visual, oculomotor and cognitive deficits associated with reading disorders.

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背视流神经调节治疗阅读障碍的新方法。

发展性阅读障碍（DD）影响了大约10%的人，损害了阅读能力，从而限制了职业成就和心理健康。DD与语音和视觉缺陷有关，后者归因于大细胞-背侧视觉流功能障碍，该功能在计划扫视和支持字母/单词身份的提取中起关键作用。目前，还没有有效的治疗方法来恢复视觉空间分析和动眼肌效率的大脑网络。成年DD患者被纳入一项随机临床试验，该试验引入了一种专门设计用于增强背流功能的非侵入性神经调节方案。我们在顶叶区域使用双焦点β波段经颅交流电刺激（tACS），因为公认的β振荡在背流功能中的作用。加上12次的视觉注意力训练，这种方案在阅读速度、眼动控制和视觉运动感知方面都有了改善。此外，β - tacs还能长期增强工作记忆。这些结果与安慰剂/假神经调节组获得的结果完全相同或优于安慰剂组，并伴有受刺激的脑网络的可塑性变化。总的来说，我们的研究结果表明，多时段tACS在改善与阅读障碍相关的核心视觉、动眼肌和认知缺陷方面是有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neurodevelopmental Disorders 医学-临床神经学

CiteScore

7.60

自引率

4.10%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Neurodevelopmental Disorders is an open access journal that integrates current, cutting-edge research across a number of disciplines, including neurobiology, genetics, cognitive neuroscience, psychiatry and psychology. The journal’s primary focus is on the pathogenesis of neurodevelopmental disorders including autism, fragile X syndrome, tuberous sclerosis, Turner Syndrome, 22q Deletion Syndrome, Prader-Willi and Angelman Syndrome, Williams syndrome, lysosomal storage diseases, dyslexia, specific language impairment and fetal alcohol syndrome. With the discovery of specific genes underlying neurodevelopmental syndromes, the emergence of powerful tools for studying neural circuitry, and the development of new approaches for exploring molecular mechanisms, interdisciplinary research on the pathogenesis of neurodevelopmental disorders is now increasingly common. Journal of Neurodevelopmental Disorders provides a unique venue for researchers interested in comparing and contrasting mechanisms and characteristics related to the pathogenesis of the full range of neurodevelopmental disorders, sharpening our understanding of the etiology and relevant phenotypes of each condition.