Intergenerational Associations of Hypertensive Disorders of Pregnancy With Offspring Metabolomics: A Systematic Review.

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Maternal-fetal medicine (Wolters Kluwer Health, Inc.) Pub Date : 2025-07-01 Epub Date: 2025-03-17 DOI:10.1097/FM9.0000000000000276

Jinrui Xiong, Ling-Jun Li, Yongping Zhang, Zhihong Zhang, Yue Yang, Huan Hu, Jinhong Liu, Zimeng Chen, Peng Huang, Mengjiao Liu

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Abstract

Objective: To examine the impact of hypertensive disorders of pregnancy (HDP) on offspring metabolomics.

Methods: We searched five databases: PubMed, Ovid Embase, MEDLINE, Web of Science, and China National Knowledge Infrastructure, and included studies that reported metabolomics among human offspring born to HDP-complicated pregnancies.

Results: Database search yielded 4054 articles, and after full-text screening, ten observational studies met inclusion criteria. Half of the studies had a sample size of less than 100 and were all observational studies in preeclampsia (PE) and gestational hypertension.Neonates were the most focused group in all included studies. Offspring born to HDP-complicated pregnancies exhibited statistically significant variations in blood metabolomics compared to their counterparts, characterized by amino acids, lipids, carnitine, and others (e.g., 1α,25-(OH)₂-D). Most studies reported a significant increase in differential metabolites of offspring born to HDP-complicated pregnancies. Four studies (n = 1109) measured lipids-related metabolites, and all consistently showed that offspring born to PE-complicated pregnancies had significantly higher concentrations than non-PE exposed offspring.

Conclusion: The existing evidence suggests an intergenerational effect of HDP on offspring metabolomics. Long-term follow-up studies are needed to advance the health effects of related adverse health outcomes and inform the prevention of offspring's health.

Registration: PROSPERO; CRD42023453078.

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妊娠高血压疾病与后代代谢组学的代际关联：一项系统综述。

目的：探讨妊娠期高血压疾病（HDP）对子代代谢组学的影响。方法：我们检索了5个数据库：PubMed、Ovid Embase、MEDLINE、Web of Science和中国国家知识基础设施数据库，并纳入了有关hdp并发症孕妇所生后代代谢组学的研究。结果：数据库检索得到4054篇文章，经过全文筛选，10项观察性研究符合纳入标准。半数研究的样本量小于100人，且均为先兆子痫（PE）和妊娠期高血压的观察性研究。在所有纳入的研究中，新生儿是最受关注的群体。与同类孕妇相比，hdp并发症孕妇所生的后代在血液代谢组学方面表现出统计学上显著的差异，其特征是氨基酸、脂质、肉碱和其他物质（例如，1α,25-(OH)2-D）。大多数研究报告了hdp并发症妊娠所生后代的差异代谢物显著增加。四项研究（n = 1109）测量了与脂质相关的代谢物，均一致表明pe并发症妊娠所生的后代的代谢物浓度显著高于未暴露pe的后代。结论：现有证据表明HDP对后代代谢组学有代际影响。需要进行长期随访研究，以促进相关不良健康结果对健康的影响，并为预防后代健康提供信息。注册:普洛斯彼罗;CRD42023453078。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Maternal-fetal medicine (Wolters Kluwer Health, Inc.)

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