Causal association between multiple sclerosis and trigeminal neuralgia: A Mendelian randomization study with meta-analysis.

IF 5.4 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Cranio-The Journal of Craniomandibular & Sleep Practice Pub Date : 2026-09-01 Epub Date: 2026-01-28 DOI:10.1080/08869634.2026.2619521

Esam Halboub, Aisha A Al-Jamaei, Abdulwahab Al-Amir, Walid A Al-Soneidar, Sadeq Ali Al-Maweri, Hesham M Al-Mekhlafi, Mohammed Nasser Alhajj

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引用次数: 0

Abstract

Objective: This study utilized a meta-analysis of two-sample Mendelian randomization (MR) to investigate the causal link between multiple sclerosis (MS) and trigeminal neuralgia (TN).

Methods: Using genetic summary data from the OpenGWAS database (European descent), researchers identified eight MS GWAS studies as exposures and one TN study as the outcome. Ten MR approaches, including IVW and MR-Egger, were employed. Pooled estimates were calculated using a fixed-effects inverse-variance model, with significance set at P < 0.05.

Results: Seven of the eight MS exposures showed a positive causal association with TN. The meta-analysis confirmed that MS significantly increases TN risk by 11% (IVW: 95% CI = 1.05-1.16; P < 0.001). Sensitivity analyses indicated no evidence of pleiotropy or heterogeneity, ensuring robust findings.

Conclusion: Genetic predisposition to MS is a causal factor for TN. Further research is required to explore underlying biological pathways and validate these results across diverse populations.

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多发性硬化症和三叉神经痛之间的因果关系：一项孟德尔随机研究和荟萃分析。

目的：本研究利用双样本孟德尔随机化（MR）的荟萃分析来探讨多发性硬化症（MS）和三叉神经痛（TN）之间的因果关系。方法：利用来自OpenGWAS数据库（欧洲血统）的遗传汇总数据，研究人员确定了8项MS GWAS研究作为暴露，1项TN研究作为结果。采用了包括IVW和MR- egger在内的10种MR方法。合并估计采用固定效应反方差模型计算，显著性设置为P < 0.05。结果：8例MS暴露中有7例与TN呈正相关。meta分析证实MS显著增加了11%的TN风险（IVW: 95% CI = 1.05-1.16; P < 0.001）。敏感性分析显示没有多效性或异质性的证据，确保了强有力的发现。结论：多发性硬化症的遗传易感性是TN的致病因素，需要进一步的研究来探索潜在的生物学途径，并在不同人群中验证这些结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cranio-The Journal of Craniomandibular & Sleep Practice DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.50

自引率

12.50%

发文量

审稿时长

>12 weeks

期刊介绍： CRANIO: The Journal of Craniomandibular & Sleep Practice is the oldest and largest journal in the world devoted to temporomandibular disorders, and now also includes articles on all aspects of sleep medicine. The Journal is multidisciplinary in its scope, with editorial board members from all areas of medicine and dentistry, including general dentists, oral surgeons, orthopaedists, radiologists, chiropractors, professors and behavioural scientists, physical therapists, acupuncturists, osteopathic and ear, nose and throat physicians. CRANIO publishes commendable works from outstanding researchers and clinicians in their respective fields. The multidisciplinary format allows individuals practicing with a TMD emphasis to stay abreast of related disciplines, as each issue presents multiple topics from overlapping areas of interest. CRANIO''s current readership (thousands) is comprised primarily of dentists; however, many physicians, physical therapists, chiropractors, osteopathic physicians and other related specialists subscribe and contribute to the Journal.