Endometrial prostaglandins in women with abnormal menstrual bleeding

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-10-01 DOI:10.1016/0262-1746(87)90014-X

I.T. Cameron , R. Leask , R.W. Kelly , D.T. Baird

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引用次数: 35

Abstract

Endogenous prostaglandin (PG) concentrations (6oxo PGF_1α, PGE, PGF_2α) have been measured by radioimmunoassay in the endaeetrium of women with objectively assessed menstrual blood loss (MBL). The concentration of PGE and “total” PG (6oxo PGF_1α+PGE+PGF _2a) was greater in the endometrium of those women with heavy menses (median MBL 152ml (range 86,432) n=16) than in those individuals with a normal menstrual loss (MBL 59m1 (18,78) n=18). The concentrations of PGE and PGF_2α were similar in each group, but the concentration of 6oxo PGF_1α was significantly less than that of both PGE and- PGF _2α. In 19 individuals, specimens of endometrium were incubated or I and 2 hours in modified 199 medium to assess PG release. There was a direct correlation between endogenous PG content and the production of 6oxo PGF_1α, PGE, PGF_2α and “total” PG in the first tour, which persisted for the second hour with PGF_2α and “total” PG. Endometrial PGs may play a role in the mechanism underlying menstruation; however the observed relationship between the prostanoids and MBL will vary with different experimental methods.

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子宫内膜前列腺素与月经异常出血的关系

用放射免疫法测定了客观评估经血损失(MBL)的女性子宫内膜内源性前列腺素(PG)浓度(6oxo PGF1α、PGE、PGF2α)。月经量大的女性子宫内膜中PGE和“总”PG (6oxo PGF1α+PGE+PGF 2a)的浓度(MBL中位数152ml(范围86,432)n=16)高于月经正常的女性(MBL 59m1 (18,78) n=18)。各组PGE和PGF2α浓度相近，但6oxo PGF1α浓度显著低于PGE和- PGF2α。在19例患者中，子宫内膜标本在改良的199培养基中孵育1小时和2小时，以评估PG的释放。内源性PG含量与子宫内膜内6oxo PGF1α、PGE、PGF2α和“总”PG的产生有直接的相关性，并在子宫内膜内持续产生PGF2α和“总”PG，子宫内膜内PG可能在月经机制中起作用;然而，观察到的前列腺素与MBL之间的关系因实验方法的不同而有所不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Prostaglandins, leukotrienes, and medicine

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