Esophageal mucosal prostaglandin E2 levels in health and in gastroesophageal reflux disease

Y. Ottignon , D. Albert, C. Moussard , J.P. Deschamps , P. Carayon , J.C. Henry
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引用次数: 19

Abstract

In vivo prostaglandin E2 (PGE2) levels were measured in esophageal mucosa excised from 9 normal subjects, 11 patients with gastroesophageal reflux without esophagitis (GER) and 8 patients with reflux esophagitis (RE). Severity of GER was quantified by postcibal pH monitoring. A manometric study was also performed. No difference was found in PGE2 levels between healthy mucosa in controls (41.7 ± 9.3 ng/g of wet tissue, at 15 cm above the lower esophageal sphincter (LES))and healthy mucosa in GER (37.8 ± 11.2 ng/g) or in RE 34.3 ± 9.0 ng/1). However, PGE2 levels were significantly enhanced within the inflammatory mucosa in RE (290.4 ± 45.7 ng/g). No difference was found in basal LES pressure between the 3 groups. These results suggest that PGE2 in the esophagus may be involved in pathogenesis of inflammation. Therefore PGE2 might not have the same cytoprotective function as in stomach or duodenum. No correlation was found between PGE2 levels in the esophagitis lesion or basal LES pressure. These data are not consistent with a possible relationship between LES pressure and the PGE2 content of the distal esophagus.

食管黏膜前列腺素E2在健康和胃食管反流疾病中的水平
测定9例正常人、11例胃食管反流无食管炎(GER)患者和8例反流性食管炎(RE)患者切除食管黏膜的体内前列腺素E2 (PGE2)水平。通过产后pH监测来量化GER的严重程度。还进行了一项测压研究。正常对照组(湿组织41.7±9.3 ng/g,位于食管下括约肌(LES)上方15 cm处)与正常对照组(37.8±11.2 ng/g)、正常对照组(34.3±9.0 ng/1)的PGE2水平无差异。RE组炎症黏膜内PGE2水平明显升高(290.4±45.7 ng/g)。3组间LES基础压无差异。这些结果提示食管PGE2可能参与炎症的发病机制。因此,PGE2可能没有胃或十二指肠中的细胞保护功能。食管炎病变的PGE2水平与LES基底压无相关性。这些数据与LES压力与食管远端PGE2含量之间的可能关系不一致。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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