Discovery and clinical significance of 1p36 chromosomal aberrations in differentiating hepatocellular carcinoma from other hepatobiliary cancers

IF 3 2区医学 Q2 PATHOLOGY

Human pathology Pub Date : 2026-05-01 Epub Date: 2026-01-23 DOI:10.1016/j.humpath.2026.106053

Wantakan Ngamsangiam , Sutheemon Techa-ay , Prakasit Sa-ngiamwibool , Sasithorn Watcharadetwittaya , Raksawan Deenonpoe , Anchalee Techasen , Adjima Luechine , Watcharin Loilome , Malinee Thanee

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引用次数: 0

Abstract

Differentiating among hepato-pancreato-biliary (HPB) cancers like cholangiocarcinoma (CCA), hepatocellular carcinoma (HCC), pancreatic cancer (PC), and gallbladder cancer (GBC) can be challenging. To address this, our study used fluorescence in situ hybridization (FISH) to identify 1p36 chromosomal abnormality patterns in 100 HPB cancer patients. We found consistent 1p36 loss in CCA, IPNB, GBC, and PC, while HCC uniquely exhibited normal, loss, and gain patterns. Notably, this 1p36 gain showed a sensitivity was 45.71 % and specificity was 100 % for differentiating HCC from CCA and other HPB cancers, while 1p36 loss proved highly sensitive (100 %) and specific (85.71 %) for distinguishing CCA from HCC, though its ability to differentiate CCA from others was limited. Beyond diagnosis, a high burden of 1p36 loss was a significant prognostic factor for shorter overall survival in CCA (p = 0.024) and in the combined CCA/IPNB cohort (p = 0.015). More importantly, 1p36 loss also significantly correlated with tumor differentiation in CCA (p < 0.05). These results suggest that assessment of 1p36 status by FISH may serve as a complementary molecular approach to conventional histopathology and immunohistochemistry, providing additional differential diagnostic HCC from CCA and other diagnostically challenging HPB cancers and serve as promising prognostic biomarkers for CCA and IPNB.

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1p36染色体畸变在肝细胞癌与其他肝胆癌鉴别中的发现及临床意义

肝-胰-胆道（HPB）癌如胆管癌（CCA）、肝细胞癌（HCC）、胰腺癌（PC）和胆囊癌（GBC）的鉴别具有挑战性。为了解决这个问题，我们的研究使用荧光原位杂交（FISH）鉴定了100例HPB癌症患者的1p36染色体异常模式。我们在CCA、IPNB、GBC和PC中发现了一致的1p36损失，而HCC独特地表现为正常、损失和增加模式。值得注意的是，该1p36增益在区分HCC与CCA和其他HPB癌方面的敏感性为45.71%，特异性为100%，而1p36损失在区分CCA和HCC方面证明了高度敏感性（100%）和特异性（85.71%），尽管其区分CCA与其他癌症的能力有限。在诊断之外，1p36损失的高负担是CCA （p = 0.024）和CCA/IPNB联合队列（p = 0.015）总生存期较短的重要预后因素。更重要的是，1p36缺失与CCA的肿瘤分化也有显著相关（p < 0.05）。这些结果表明，FISH对1p36状态的评估可以作为传统组织病理学和免疫组织化学的补充分子方法，为CCA和其他诊断上具有挑战性的HPB癌症提供额外的HCC鉴别诊断，并作为CCA和IPNB的有希望的预后生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human pathology 医学-病理学

CiteScore

5.30

自引率

6.10%

发文量

206

审稿时长

21 days

期刊介绍： Human Pathology is designed to bring information of clinicopathologic significance to human disease to the laboratory and clinical physician. It presents information drawn from morphologic and clinical laboratory studies with direct relevance to the understanding of human diseases. Papers published concern morphologic and clinicopathologic observations, reviews of diseases, analyses of problems in pathology, significant collections of case material and advances in concepts or techniques of value in the analysis and diagnosis of disease. Theoretical and experimental pathology and molecular biology pertinent to human disease are included. This critical journal is well illustrated with exceptional reproductions of photomicrographs and microscopic anatomy.