Efficacy of a transdiagnostic guided internet-delivered intervention for anxiety, depression, trauma and stress-related symptoms: A randomized controlled trial

IF 1.9 3区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Contemporary clinical trials Pub Date : 2026-03-01 Epub Date: 2026-01-20 DOI:10.1016/j.cct.2026.108229

Anabel de la Rosa Gómez , Pablo D. Valencia , Dulce M. Díaz Sosa , Lorena Alejandra Flores Plata , Raquel García Flores , Carolina Santillán Torres Torija , Alejandra Mares Portillo , Alfonso Mendoza Leal , Alicia Ivet Flores Elvira , Esteban Eugenio Esquivel-Santoveña , Enrique Berra Ruiz

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引用次数: 0

Abstract

Objective

There is strong evidence that online transdiagnostic interventions are effective in treating anxiety and depression, and contribute to improving patients' quality of life. This study aimed to evaluate the efficacy and acceptability of an internet-guided transdiagnostic intervention (guided UP) versus a self-guided internet-based transdiagnostic intervention (unguided UP) for the transdiagnostic treatment of emotional disorders targeting the Mexican community.

Methods

A randomized clinical trial was conducted to compare therapist-supported online transdiagnostic treatment with an unguided version and a waiting list control group. 247 individuals aged 18 to 70 years were assessed at four time points (before and after treatment, three and six months follow- up) to identify levels of anxiety, depression, trauma and stress-related symptoms. Participants who qualified and decided to participate were randomly assigned to one of three conditions.

Results

Higher levels of acceptability, satisfaction, and suitability were reported for the intervention with therapeutic support compared to the UP-unguided condition. After treatment, significant mean differences were found between the waitlist group and both the UP-guided and unguided groups in anxiety, depression, trauma and stress-related symptoms, and general distress, as well as in emotional dysregulation for the guided group only, all with large effect sizes. Direct comparisons between the UP-guided and unguided groups showed significant differences favoring the UP-guided treatment at post-test for depression and emotional dysregulation. However, at the 3- and 6-month follow-ups, the UP-unguided group continued to improve, whereas the UP-guided group tended to remain stable. As a result, by the end of the follow-up period, the UP-unguided group showed significantly lower levels of anxiety, PTSD symptoms, and emotional dysregulation.

Conclusions

The study supports the preliminary evidence of the clinical utility of UP online interventions in a specific sample recruited for the treatment of anxiety, depression, trauma and stress-related symptoms with the advantage of reaching a larger number of people. Even though the UP-unguided intervention showed clinical utility, the support of a therapist in an online intervention could offer an advantage that improves treatment adherence and, in particular, resulted in a greater reduction in symptoms of depression and emotional dysregulation, making it the superior option from a clinical perspective.

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一种跨诊断引导互联网干预焦虑、抑郁、创伤和压力相关症状的疗效：一项随机对照试验

目的：有强有力的证据表明，在线跨诊断干预在治疗焦虑和抑郁方面是有效的，并有助于提高患者的生活质量。本研究旨在评估互联网引导的跨诊断干预（guided UP）与自我引导的基于互联网的跨诊断干预（unguided UP）在针对墨西哥社区的情绪障碍跨诊断治疗中的疗效和可接受性。方法：进行一项随机临床试验，比较治疗师支持的在线跨诊断治疗与无指导的版本和等待名单对照组。247名年龄在18至70岁 岁之间的个体在四个时间点（治疗前后，3个月和6个月的随访）进行评估，以确定焦虑、抑郁、创伤和压力相关症状的水平。符合条件并决定参加的参与者被随机分配到三种情况中的一种。结果：与UP-unguided条件相比，有治疗性支持的干预具有更高的可接受性、满意度和适宜性。治疗后，等候组与up指导组和未指导组在焦虑、抑郁、创伤和压力相关症状、一般痛苦以及仅指导组的情绪失调方面均存在显著的平均差异，均具有较大的效应量。向上引导组和非向上引导组之间的直接比较显示，在抑郁和情绪失调的后测试中，向上引导治疗有显著差异。然而，在3个月和6个月的随访中，无up指导组继续改善，而up指导组趋于稳定。结果，在随访期结束时，未接受up指导的组表现出明显较低的焦虑、PTSD症状和情绪失调水平。结论：该研究支持了UP在线干预在特定样本中的临床效用的初步证据，该样本用于治疗抑郁、焦虑、抑郁、创伤和压力相关症状，其优势是可以覆盖更多的人群。尽管UP-unguided intervention显示了临床效用，但治疗师在在线干预中的支持可以提供一个优势，即提高治疗依从性，特别是导致抑郁和情绪失调症状的更大减少，从临床角度来看，使其成为更好的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contemporary clinical trials 医学-药学

CiteScore

3.70

自引率

4.50%

发文量

281

审稿时长

44 days

期刊介绍： Contemporary Clinical Trials is an international peer reviewed journal that publishes manuscripts pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from disciplines including medicine, biostatistics, epidemiology, computer science, management science, behavioural science, pharmaceutical science, and bioethics. Full-length papers and short communications not exceeding 1,500 words, as well as systemic reviews of clinical trials and methodologies will be published. Perspectives/commentaries on current issues and the impact of clinical trials on the practice of medicine and health policy are also welcome.