A multilevel clinic- and community-based intervention to increase COVID-19 vaccination among Latinos in San Diego County: Protocol description of the vaccine promotion program

IF 1.9 3区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Contemporary clinical trials Pub Date : 2026-03-01 Epub Date: 2026-01-19 DOI:10.1016/j.cct.2026.108227

Noe C. Crespo , John Elder , Eyal Oren , Elva Arredondo , Chii-Dean Joey Lin , Job Godino , Hala Madanat , Griselda Cervantes , Amanda Patron , Kiria Fraga , Bianca Vargas-Tequida , Christian B. Ramers

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引用次数: 0

Abstract

Background

COVID-19 has disproportionately affected minority groups, including Latinos. Since the development of COVID-19 vaccines, effective implementation faced challenges due to multiple factors, necessitating multi-level and multi-sector approaches. This study describes the Vaccine Promotion Program (VPP), a multi-level intervention to increase COVID-19 vaccine uptake among Latinos in clinical and community settings.

Methods

VPP is a double-blind, pragmatic, 12-month cluster-randomized trial in collaboration with a large Federally Qualified Health Center (FQHC) in San Diego, CA. Ten clinics will be randomized to a Multilevel Intervention involving activities at the interpersonal, clinic, and community levels (VPP) or Standard Clinical Practice (SCP) (n = 5 clinics, respectively). Patients in VPP clinics will receive tailored clinic-originated messages about COVID-19 vaccination and motivational interviews (MI) (15–30-min telephone/telehealth encounters) from Health Educators (HE) to encourage COVID-19 vaccination. HEs will send emails and/or text message-based information to encourage vaccination. The community-level intervention involves targeted and tailored activities to promote COVID-19 vaccine uptake in neighborhoods surrounding the five VPP clinics. A cohort of 200 patients will be enrolled to participate in comprehensive surveys and follow-up for 24 months to assess longer-term outcomes. The primary outcome (COVID-19 aggregated vaccination rates) will be compared at baseline, 6, and 12 months between VPP and SCP clinics and neighborhoods, respectively.

Discussion

VPP directly addresses the most prominent COVID-19 vaccination barriers, including health literacy, community trust, and vaccine access, through a multi-level approach in collaboration with an FQHC. This approach has the potential to be an effective and scalable public health approach to vaccination among underserved communities.

查看原文本刊更多论文

在圣地亚哥县开展多层次诊所和社区干预，以增加拉丁裔人的COVID-19疫苗接种：疫苗推广计划的方案描述。

背景：2019冠状病毒病对包括拉丁美洲人在内的少数群体的影响尤为严重。自COVID-19疫苗开发以来，实施工作面临多种因素的挑战，需要采取多层次、多部门的方法。本研究描述了疫苗推广计划（VPP），这是一项旨在提高临床和社区环境中拉丁裔人COVID-19疫苗接种率的多层次干预措施。方法：VPP是一项双盲、实用的、为期12个月的集群随机试验，与加利福尼亚州圣地亚哥的一家大型联邦合格健康中心（FQHC）合作。10家诊所将被随机分配到涉及人际、诊所和社区层面活动的多层次干预（VPP）或标准临床实践（SCP）（n = ，各5家诊所）。VPP诊所的患者将收到量身定制的诊所发起的关于COVID-19疫苗接种的信息和健康教育者的动机性访谈（15-30分钟的电话/远程医疗接触），以鼓励接种COVID-19疫苗。卫生主任将发送电子邮件和/或短信信息，鼓励接种疫苗。社区层面的干预包括有针对性和量身定制的活动，以促进五个VPP诊所周围社区的COVID-19疫苗接种。将招募200名患者参加综合调查和随访24 个月，以评估长期结果。将分别在基线、6和12 个月比较VPP和SCP诊所和社区的主要结局（COVID-19总疫苗接种率）。讨论：VPP通过与FQHC合作的多层次方法，直接解决最突出的COVID-19疫苗接种障碍，包括卫生素养、社区信任和疫苗获取。这种方法有可能成为在服务不足的社区进行疫苗接种的有效和可扩展的公共卫生方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contemporary clinical trials 医学-药学

CiteScore

3.70

自引率

4.50%

发文量

281

审稿时长

44 days

期刊介绍： Contemporary Clinical Trials is an international peer reviewed journal that publishes manuscripts pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from disciplines including medicine, biostatistics, epidemiology, computer science, management science, behavioural science, pharmaceutical science, and bioethics. Full-length papers and short communications not exceeding 1,500 words, as well as systemic reviews of clinical trials and methodologies will be published. Perspectives/commentaries on current issues and the impact of clinical trials on the practice of medicine and health policy are also welcome.