Prostaglandin production by human myometrium, uterine cervix and leiomyoma

Abstract

In order to investigate prostacyclin production by human myometrium, uterine cervix and leiomyoma, slices of each tissue were incubated.The 6-keto prostaglandin F_1α concentration of the incubation medium was measured by radioimmunoassay. The serosal and endometrial sides of myometrium produce 6-keto prostaglandin F_1α, with no significant difference in production between the two sides. The 6-keto PGF_1α production of leiomyoma was significantly higher than that of myometrium. Our results suggest that human myometrium and leiomyoma produce prostacyclin regardless of vascularization.