Malignant Craniopharyngioma With Features Resembling Ghost Cell Odontogenic Carcinoma: A Case Report and Histopathology Literature Review.

IF 1.3 4区医学 Q4 CLINICAL NEUROLOGY

Neuropathology Pub Date : 2026-02-01 DOI:10.1111/neup.70043

Sompon Apornvirat, Pitchayanant Laemad, Bhannaporn Limsuksrikul, Phirasit Chaijitrawan, Putch Phairintr, Raywat Noiphithak

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引用次数: 0

Abstract

Malignant transformation of craniopharyngioma is an exceptionally rare and poorly characterized phenomenon. We report a case of a 15-year-old girl who developed symptom recurrence 9 years after undergoing surgery and radiotherapy for adamantinomatous craniopharyngioma. Histology revealed malignant areas comprising highly proliferative basaloid cells with abrupt transitions into ghost cells, resembling ghost cell odontogenic carcinoma. We conducted a literature review and pooled case analysis of 45 cases, which showed a median benign-to-malignant latency of 10 years and a median overall survival of 9 months. The majority of benign diagnoses were adamantinomatous type. Prior radiotherapy was noted in 27 cases (60%). Histological findings of malignant components were reported as unspecified malignant transformation in 20 cases (44.4%), squamous cell carcinoma (SCC) in 16 cases (35.6%), odontogenic-type carcinomas in 5 cases (11.1%), and other types in 4 cases (8.9%). Immunohistochemical analyses showed consistent positivity for pan-cytokeratin, p63, and p40 in all cases performed. The p53 and Ki-67 also consistently exhibited increased or abnormal expression. Due to the overlapping histological and immunohistochemical features of odontogenic-type carcinomas and SCC, careful assessment is recommended when diagnosing recurrent CPs.

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具有类似鬼细胞牙源性癌特征的恶性颅咽管瘤1例报告及组织病理学文献复习。

颅咽管瘤的恶性转化是一种非常罕见且特征不明确的现象。我们报告一个15岁的女孩，在接受手术和放疗9年后出现症状复发的金刚瘤性颅咽管瘤。组织学显示，恶性区域包括高度增殖的基底样细胞，并突然转变为鬼细胞，类似鬼细胞牙源性癌。我们对45例病例进行了文献回顾和汇总病例分析，结果显示中位良恶性潜伏期为10年，中位总生存期为9个月。良性诊断以硬瘤型居多。既往放疗27例（60%）。恶性成分组织学表现为未明确的恶性转化20例（44.4%），鳞状细胞癌16例（35.6%），牙源性癌5例（11.1%），其他类型4例（8.9%）。免疫组织化学分析显示，所有病例的泛细胞角蛋白、p63和p40均呈一致阳性。p53和Ki-67的表达也持续增加或异常。由于牙源性癌和鳞状细胞癌的组织学和免疫组织化学特征重叠，建议在诊断复发性CPs时仔细评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropathology 医学-病理学

CiteScore

4.10

自引率

4.30%

发文量

105

审稿时长

6-12 weeks

期刊介绍： Neuropathology is an international journal sponsored by the Japanese Society of Neuropathology and publishes peer-reviewed original papers dealing with all aspects of human and experimental neuropathology and related fields of research. The Journal aims to promote the international exchange of results and encourages authors from all countries to submit papers in the following categories: Original Articles, Case Reports, Short Communications, Occasional Reviews, Editorials and Letters to the Editor. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.