Emerging role of NEAT1 in skin pathology: from molecular regulation to clinical applications

IF 2.7 3区生物学 Q2 GENETICS & HEREDITY

Gene Pub Date : 2026-04-05 Epub Date: 2026-01-16 DOI:10.1016/j.gene.2026.150013

Wiam Saadi , Ahlam Fatmi , Auda Ameur , Salvatore Spicuglia , Denis Puthier , Mohamed Belhocine

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Abstract

Long non-coding RNAs (lncRNAs) are increasingly recognized as crucial regulators of gene expression, influencing a wide array of physiological and pathological processes. Among these, Nuclear Enriched Abundant Transcript 1 (NEAT1), an essential component of nuclear paraspeckles, has garnered significant attention for its diverse roles in various diseases, including immune-related disorders and certain cancers. While the involvement of lncRNAs in dermatologic conditions is an expanding field, the specific implications of NEAT1 in the onset and progression of skin diseases remain largely underexplored. This review aims to consolidate current knowledge regarding the multifaceted roles of NEAT1 in skin biology and pathology. Here, we summarize available evidence on NEAT1 in skin disorders, emphasizing its roles in regulating keratinocyte biology, modulating inflammatory pathways, and influencing disease progression. By consolidating current findings, the review provides a framework for understanding the potential role of NEAT1 as a biomarker and therapeutic target in dermatologic conditions.

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NEAT1在皮肤病理中的新作用：从分子调控到临床应用。

长链非编码rna （lncRNAs）越来越被认为是基因表达的重要调控因子，影响着一系列广泛的生理和病理过程。其中，核富集丰富转录本1 （Nuclear enrichment Abundant Transcript 1, NEAT1）是核副斑的重要组成部分，因其在多种疾病（包括免疫相关疾病和某些癌症）中的多种作用而受到广泛关注。虽然lncrna在皮肤疾病中的参与是一个不断扩大的领域，但NEAT1在皮肤疾病发生和进展中的具体含义仍未得到充分探讨。这篇综述旨在巩固目前关于NEAT1在皮肤生物学和病理学中的多方面作用的知识。在这里，我们总结了NEAT1在皮肤疾病中的现有证据，强调了它在调节角质形成细胞生物学、调节炎症通路和影响疾病进展中的作用。通过巩固目前的研究结果，本综述为理解NEAT1作为生物标志物和皮肤病治疗靶点的潜在作用提供了一个框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene 生物-遗传学

CiteScore

6.10

自引率

2.90%

发文量

718

审稿时长

42 days

期刊介绍： Gene publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses.