{"title":"Active Inference as a theoretical framework for external locus of control in chronic pain: the role of aberrant interoceptive integration","authors":"Yuri Cordeiro Szeremeta","doi":"10.1016/j.mehy.2026.111878","DOIUrl":null,"url":null,"abstract":"<div><div>Perceived control is a transdiagnostic feature across chronic pain. The Locus of Control is a patient’s personality trait that refers to a belief about the extent to which they have control over their health outcomes. From a phenomenological point of view, the prevalence of internal or external dimensions of Locus of Control indicates how individuals operate certain cognitive systems and how they perceive different forces that influence their lives. Consequently, it is a key indicator of whether treatment will be successful or unsuccessful. However, the neural pathways and belief systems that underlie this personality trait remain poorly understood. This article raises the hypothesis that the theoretical basis of <em>Active Inference</em> may explain a propensity for external Locus of Control in chronic pain sufferers.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"208 ","pages":"Article 111878"},"PeriodicalIF":1.0000,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical hypotheses","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306987726000071","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/12 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Perceived control is a transdiagnostic feature across chronic pain. The Locus of Control is a patient’s personality trait that refers to a belief about the extent to which they have control over their health outcomes. From a phenomenological point of view, the prevalence of internal or external dimensions of Locus of Control indicates how individuals operate certain cognitive systems and how they perceive different forces that influence their lives. Consequently, it is a key indicator of whether treatment will be successful or unsuccessful. However, the neural pathways and belief systems that underlie this personality trait remain poorly understood. This article raises the hypothesis that the theoretical basis of Active Inference may explain a propensity for external Locus of Control in chronic pain sufferers.
期刊介绍:
Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.