Genetic analysis workshop IV: summary of two-point and multipoint mapping of 11p.

Abstract

The seven loci: insulin (INS), oncogene c-Ha-ras-1 (HRASl), ADJ (DllS12) , D-globin (HBBC) , parathyroid hormone (PTH) , calcitonin (CALC1) and catalase (CAT) have all been assigned to the short arm of chromosome 11 (Human Gene Mapping Workshop 8). Results from 2-point linkage analysis using DNA polymorphisms for these loci gave the linkage map: centromere: CAT CALCl PTH HBBC DllS12 (HRAS1: INS). The HBBC and DllS12 loci are relatively tightly linked to the HRASl and INS loci. Because the HRASl and INS loci are tightly linked (only a few cM apart), it had not been possible to order them definitively in previous linkage studies (Antonarakis et al., 1983; Fearon et al., 1984; Kittur et al., 1985; White et al., 1985).