Characteristics and Outcomes of Acute Leukemias in Adolescents and Young Adults with Down Syndrome: A Single-Center Experience.

IF 1.9 Q4 HEMATOLOGY

Hematology Reports Pub Date : 2025-12-18 DOI:10.3390/hematolrep17060070

Marie Nour Karam, Sandra K Althouse, Madeline G Andrews, Jenny Chen, Sandeep Batra

引用次数: 0

Abstract

Background/Objectives: Acute leukemias in adolescents and young adults (AYAs) with Down Syndrome (DS) are understudied. Methods: This was a single-center, retrospective cohort study. Medical records for pediatric DS (n = 41) and AYA-DS (n = 7) treated with a pediatric chemotherapy regimen for acute leukemia were evaluated. Results: Two-year event-free survival (EFS) in AYA DS acute leukemia patients was lower than that in their pediatric DS counterparts (28.6% (Confidence Interval (CI) 4.1, 61.2) vs. 84.9% (CI 69.5, 92.9); p = 0.002). Conclusions: Additional research is needed to improve outcomes in AYA DS leukemia.

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唐氏综合征青少年和青年急性白血病的特点和结局：单中心研究

背景/目的：唐氏综合征（DS）青少年和青壮年（AYAs）急性白血病的研究尚不充分。方法：这是一项单中心、回顾性队列研究。对急性白血病儿童化疗方案治疗的儿童DS （n = 41）和AYA-DS （n = 7）的医疗记录进行评估。结果：AYA DS急性白血病患者的两年无事件生存率（EFS）低于儿科DS患者(28.6%（置信区间（CI） 4.1, 61.2）比84.9% (CI 69.5, 92.9)；P = 0.002)。结论：需要进一步的研究来改善AYA DS白血病的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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