Antibiotic residues in pork in 3 provinces of Lao PDR and risk assessment.

IF 2.5 3区农林科学 Q2 CHEMISTRY, APPLIED

Food additives & contaminants. Part B, Surveillance Pub Date : 2026-03-01 Epub Date: 2025-12-19 DOI:10.1080/19393210.2025.2595626

Chamina Ounsily, Khamla Phonsayalinkham, Sounantha Souvanlasy, Sysay Palamy, Chithdavone Her, Oudone Chanthavong, Santi Kongmany, Noudy Sengxeu

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引用次数: 0

Abstract

This study investigated the prevalence and residue levels of the antibiotics amoxycillin, ampicillin, oxytetracycline, and tetracycline in pork sold at fresh markets in Vientiane Capital, Luang Prabang, and Champasak provinces of Lao PDR. A total of 72 pork samples were analysed using electrospray ionisation liquid chromatography - tandem mass spectrometry (ESI-LC-MS/MS). Antibiotic residues were detected in 56.9% of the samples and 4.2% exceeded the Maximum Residue Limit (MRL). Tetracycline (47.2%) was most frequently detected, with a mean residue level of 5.3 µg/kg, followed by oxytetracycline (31.9%; mean: 11.8 µg/kg) and amoxycillin (8.3%; mean: 52.3 µg/kg). Ampicillin was not detected in any sample. Health risk assessment using the Hazard index (HI) indicated no health risks under the current dietary exposure. However, the presence of multiple residues in single samples raises concerns about cumulative exposure and potential contribution to antimicrobial resistance, highlighting the need for farmer training, enforcement of withdrawal periods and regular monitoring to protect public health in Lao PDR.

查看原文本刊更多论文

老挝人民民主共和国3个省猪肉中的抗生素残留及其风险评估。

本研究调查了老挝人民民主共和国首都万象、琅勃拉邦和占巴塞省生鲜市场销售的猪肉中抗生素阿莫西林、氨苄西林、土霉素和四环素的流行情况和残留水平。采用电喷雾电离液相色谱-串联质谱（ESI-LC-MS/MS）对72份猪肉样品进行了分析。56.9%的样品检出抗生素残留，4.2%超过最大残留限量（MRL）。其中四环素（47.2%）的残留量最高，平均残留量为5.3µg/kg，其次是土霉素（31.9%）和阿莫西林（8.3%），平均残留量为52.3µg/kg。未检出氨苄西林。使用危害指数（HI）进行的健康风险评估表明，在目前的饮食暴露下没有健康风险。然而，单个样品中存在多种残留物引起了对累积接触和可能导致抗菌素耐药性的关注，突出表明需要对农民进行培训、强制执行撤药期和定期监测，以保护老挝人民民主共和国的公众健康。

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来源期刊

Food additives & contaminants. Part B, Surveillance 农林科学-毒理学

CiteScore

5.30

自引率

10.30%

发文量

审稿时长

2.7 months

期刊介绍： Food Additives & Contaminants: Part B publishes surveillance data indicating the presence and levels of occurrence of designated food additives, residues and contaminants in foods, food supplements and animal feed. Data using validated methods must meet stipulated quality standards to be acceptable and must be presented in a prescribed format for subsequent data-handling. Food Additives & Contaminants: Part B restricts its scope to include certain classes of food additives, residues and contaminants. This is based on a goal of covering those areas where there is a need to record surveillance data for the purposes of exposure and risk assessment. The scope is initially restricted to: Additives - food colours, artificial sweeteners, and preservatives; Residues – veterinary drug and pesticide residues; Contaminants – metals, mycotoxins, phycotoxins, plant toxins, nitrate/nitrite, PCDDs/PCFDs, PCBs, PAHs, acrylamide, 3-MPCD and contaminants derived from food packaging. Readership: The readership includes scientists involved in all aspects of food safety and quality and particularly those involved in monitoring human exposure to chemicals from the diet. Papers reporting surveillance data in areas other than the above should be submitted to Part A . The scope of Part B will be expanded from time-to-time to ensure inclusion of new areas of concern.