Congestive Heart Failure: Perioperative Risk Assessment and Therapeutic Consequences.

IF 7.1 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Vera von Dossow, Giovanni Lurati Buse, Tau Hartikainen, Martin Mirus, Johannes T Neumann
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Abstract

Background: Three million people in Germany, and approximately 20% of older people undergoing surgery, suffer from chronic congestive heart failure. Perioperative hospital mortality is 4.8% in patients known to have chronic congestive heart failure and only 0.78% in other patients (adjusted odds ratio 2.15, 95% confidence interval [2.09; 2.22]). Congestive heart failure is often inadequately diagnosed and treated, and there is often a lack of preoperative guideline-based risk assessment and individualized strategic planning.

Methods: This narrative review is based on pertinent guidelines and publications retrieved by a selective literature search (PubMed/Medline).

Results: The frequency of acute postoperative decompensation is 2.5% among the entire population of patients with congestive heart failure (whether newly diagnosed or previously present as a chronic condition). The 1-year mortality rate is 44% (which can be compared to 11% without cardiac decompensation; adjusted HR, 1.66 [1.3; 2.2]). Patients at risk should be identified and classified at an early stage with biomarker screening and echocardiography so that they can be managed perioperatively in accordance with the guidelines. Extended cardiovascular monitoring (preload, contractility, afterload) enables individualized volume and fluid substitution. Frequent reexamination in the early postoperative phase allows clinical deterioration to be detected early and treated with drugs. After discharge, the patient's further course must be monitored by his or her primary care physician.

Conclusion: Guideline-based pharmacotherapy, risk stratification, and interdisciplinary perioperative monitoring at close intervals are indispensable for lowering risk and preventing acute decompensation. Randomized clinical trials have been performed for the general treatment of congestive heart failure, but not for its perioperative management.

充血性心力衰竭:围手术期风险评估和治疗后果。
背景:在德国有300万人患有慢性充血性心力衰竭,大约20%的老年人接受手术。已知慢性充血性心力衰竭患者围手术期住院死亡率为4.8%,其他患者仅为0.78%(校正优势比2.15,95%可信区间[2.09;2.22])。充血性心力衰竭的诊断和治疗往往不充分,而且往往缺乏术前基于指南的风险评估和个性化的战略规划。方法:本综述基于相关指南和选择性文献检索(PubMed/Medline)检索到的出版物。结果:在整个充血性心力衰竭患者(无论是新诊断的还是以前作为慢性疾病存在的)中,急性术后失代偿的频率为2.5%。1年死亡率为44%(未发生心脏失代偿时为11%,调整后HR为1.66[1.3;2.2])。高危患者应在早期阶段通过生物标志物筛查和超声心动图进行识别和分类,以便根据指南对其进行围手术期管理。扩展心血管监测(负荷前、收缩性、负荷后)可实现个体化容量和液体替代。术后早期频繁复查,可以及早发现临床恶化,并给予药物治疗。出院后,病人的进一步病程必须由他或她的初级保健医生监测。结论:以指南为基础的药物治疗、风险分层、围手术期跨学科密切监测是降低风险和预防急性失代偿不可缺少的。随机临床试验已经进行了充血性心力衰竭的一般治疗,但没有对其围手术期管理。
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来源期刊
Deutsches Arzteblatt international
Deutsches Arzteblatt international 医学-医学:内科
CiteScore
4.10
自引率
5.20%
发文量
306
审稿时长
4-8 weeks
期刊介绍: Deutsches Ärzteblatt International is a bilingual (German and English) weekly online journal that focuses on clinical medicine and public health. It serves as the official publication for both the German Medical Association and the National Association of Statutory Health Insurance Physicians. The journal is dedicated to publishing independent, peer-reviewed articles that cover a wide range of clinical medicine disciplines. It also features editorials and a dedicated section for scientific discussion, known as correspondence. The journal aims to provide valuable medical information to its international readership and offers insights into the German medical landscape. Since its launch in January 2008, Deutsches Ärzteblatt International has been recognized and included in several prestigious databases, which helps to ensure its content is accessible and credible to the global medical community. These databases include: Carelit CINAHL (Cumulative Index to Nursing and Allied Health Literature) Compendex DOAJ (Directory of Open Access Journals) EMBASE (Excerpta Medica database) EMNursing GEOBASE (Geoscience & Environmental Data) HINARI (Health InterNetwork Access to Research Initiative) Index Copernicus Medline (MEDLARS Online) Medpilot PsycINFO (Psychological Information Database) Science Citation Index Expanded Scopus By being indexed in these databases, Deutsches Ärzteblatt International's articles are made available to researchers, clinicians, and healthcare professionals worldwide, contributing to the global exchange of medical knowledge and research.
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