Resistant starch improves Parkinson’s disease symptoms through restructuring of the gut microbiome and modulating inflammation

IF 7.5 2区医学 Q1 IMMUNOLOGY

Brain, Behavior, and Immunity Pub Date : 2026-02-01 Epub Date: 2025-12-11 DOI:10.1016/j.bbi.2025.106217

Viacheslav A. Petrov , Sebastian Schade , Cedric C. Laczny , Jenny Hällqvist , Patrick May , Christian Jäger , Velma T.E. Aho , Oskar Hickl , Rashi Halder , Elisabeth Lang , Jordan Caussin , Laura A. Lebrun , Janine Schulz , Marcus Michael Unger , Kevin Mills , Brit Mollenhauer , Paul Wilmes

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引用次数: 0

Abstract

Alterations in the gut microbiome and a “leaky” gut are associated with Parkinson’s disease (PD), which implies the prospect of rebalancing via dietary intervention. Here, we investigate the impact of a diet rich in resistant starch on the gut microbiome through a multi-omics approach. We conducted a randomized, controlled trial with short-term and long-term phases involving 74 PD patients of three groups: conventional diet, supplementation with resistant starch, and high-fibre diet.

Our findings reveal associations between dietary patterns and changes in the gut microbiome’s taxonomic composition, functional potential, metabolic activity, and host inflammatory proteome response. Resistant starch supplementation led to an increase in Faecalibacterium species and short-chain fatty acids alongside a reduction in opportunistic pathogens. Long-term supplementation also increased blood APOA4 and HSPA5 and reduced symptoms of PD.

Our study highlights the potential of dietary interventions to modulate the gut microbiome and improve the quality of life for PD patients.

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抗性淀粉通过重组肠道微生物群和调节炎症来改善帕金森病症状。

肠道微生物群的改变和肠道“渗漏”与帕金森病（PD）有关，这意味着通过饮食干预来重新平衡的前景。在这里，我们通过多组学方法研究了富含抗性淀粉的饮食对肠道微生物组的影响。我们进行了一项短期和长期的随机对照试验，涉及74名PD患者，分为三组：常规饮食、补充抗性淀粉和高纤维饮食。我们的研究结果揭示了饮食模式与肠道微生物组的分类组成、功能潜力、代谢活性和宿主炎症蛋白质组反应的变化之间的联系。抗性淀粉的补充导致粪杆菌种类和短链脂肪酸的增加和机会致病菌的减少。长期补充也增加了血液APOA4和HSPA5，减轻了PD的症状。我们的研究强调了饮食干预在调节肠道微生物群和改善PD患者生活质量方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain, Behavior, and Immunity 医学-免疫学

CiteScore

29.60

自引率

2.00%

发文量

290

审稿时长

28 days

期刊介绍： Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals. As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.