Differing effects of chronic ethanol consumption by mice on liver microsomal metabolism of xenobiotics: 1-nitropyrene, nicotine, aniline, and N-nitrosopyrrolidine.

Molecular toxicology Pub Date : 1987-04-01
P C Howard, G J DeMarco, M C Consolo, G D McCoy
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Abstract

The effect of ethanol consumption by male CF-1 mice on liver microsomal enzyme activities has been investigated. The total microsomal cytochrome P-450 content was increased by 38%, while cytochrome b5 was decreased by 31%, which are characteristic alterations in liver microsomes following ethanol consumption. Other alterations included a decreased NADPH cytochrome c reductase activity and increased NADPH-supported rates of N-nitrosopyrrolidine and aniline hydroxylation. While ethanol consumption did not alter the total metabolism of nicotine, the rates of N- and C-hydroxylation were differently affected. The 5'-hydroxylation of nicotine was increased by 83%, while the N'-oxidation was decreased by 31%. Changes in the microsomal metabolism of the environmental carcinogen 1-nitropyrene included a slight reduction in the overall metabolism, which can be accounted for by a reduction in the formation of one phenolic metabolite, 1-nitropyren-3-ol.

慢性乙醇消耗对小鼠肝微粒体代谢的不同影响:1-硝基芘、尼古丁、苯胺和n -亚硝基吡咯烷。
研究了雄性CF-1小鼠摄入乙醇对肝微粒体酶活性的影响。微粒体总细胞色素P-450含量增加了38%,而细胞色素b5含量减少了31%,这是乙醇消耗后肝微粒体的特征性变化。其他变化包括NADPH细胞色素c还原酶活性降低,NADPH支持的n -亚硝基吡罗烷和苯胺羟基化率增加。虽然乙醇消耗没有改变尼古丁的总代谢,但N-和c -羟基化的速率受到不同程度的影响。烟碱的5′-羟基化活性提高了83%,N′-氧化活性降低了31%。环境致癌物1-硝基芘微粒体代谢的变化包括总体代谢的轻微减少,这可以通过一种酚类代谢物1-硝基芘-3-醇的形成减少来解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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