Linking Premenstrual Syndrome With Salivary Alpha-Amylase Levels and Stress Levels: A Cross-Sectional Study.

Journal of Family and Reproductive Health Pub Date : 2025-09-01 DOI:10.18502/jfrh.v19i3.20058

Gabriyah Hamzah, Aryadi Arsyad, Elizabet C Jusuf

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Abstract

Objective: This study aims to analyze the correlation between salivary alpha-amylase (sAA) and stress in adolescents with premenstrual syndrome (PMS), and to assess the predictive ability of sAA levels and stress for PMS.

Materials and methods: Sixty-two adolescents with and without PMS (31 each) were grouped based on their PMS status, measured using the Shortened Premenstrual Assessment Form (SPAF). Stress was measured using the Kessler Psychological Distress Scale (K10). The levels of sAA were measured using Enzyme-Linked Immunosorbent Assay (ELISA). Data were analyzed using the Pearson correlation test, Receiver Operating Characteristic (ROC) curve analysis, and multiple linear regression analysis.

Results: Stress and PMS expressed a significant positive correlation (p=0.001; r=0.66). sAA levels and PMS showed a significant positive correlation (p<0.05; r=0.42). The level of sAA in adolescents with PMS was 23.28±12.02 ng/mL, almost twice higher than in adolescents without PMS (12.10±7.5 ng/mL). The cut-off value of sAA level on PMS was ≥15.02 ng/mL with a sensitivity and specificity of 67.7%. The level of sAA and stress were significantly able to predict PMS (p<0.001). The correlation value of SAA levels and stress with PMS is positive (r=0.705), suggesting they can predict PMS by 49.7% (R²=0.497).

Conclusion: There is a positive relationship between sAA levels and stress in adolescents with PMS. SAA levels and stress were able to predict PMS in adolescents with an accuracy of 49.7%.

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经前综合征与唾液α -淀粉酶水平和应激水平的联系：一项横断面研究。

目的：分析青少年经前综合征（PMS）患者唾液α -淀粉酶（sAA）水平与应激的相关性，探讨sAA水平与应激对PMS的预测能力。材料与方法：采用缩短经前评估表（SPAF）对62名有经前综合症和无经前综合症的青少年（各31名）进行经前综合症分组。使用Kessler心理困扰量表（K10）测量压力。采用酶联免疫吸附试验（ELISA）测定血清sAA水平。采用Pearson相关检验、受试者工作特征（ROC）曲线分析和多元线性回归分析对资料进行分析。结果：应激与PMS呈显著正相关（p=0.001; r=0.66）。sAA水平与PMS呈显著正相关（p2=0.497）。结论：经前症候群青少年sAA水平与应激水平呈正相关。SAA水平和压力能够预测青少年经前综合症，准确率为49.7%。

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来源期刊

Journal of Family and Reproductive Health

自引率

0.00%

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审稿时长

5 weeks

期刊介绍： The Journal of Family & Reproductive Health (JFRH) is the quarterly official journal of Vali–e–Asr Reproductive Health Research Center. This journal features fulllength, peerreviewed papers reporting original research, clinical case histories, review articles, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology including genetics, endocrinology, andrology, embryology, gynecologic urology, fetomaternal medicine, oncology, infectious disease, public health, nutrition, surgery, menopause, family planning, infertility, psychiatry–psychology, demographic modeling, perinatalogy–neonatolgy ethics and social issues, and pharmacotherapy. A high scientific and editorial standard is maintained throughout the journal along with a regular rate of publication. All published articles will become the property of the JFRH. The editor and publisher accept no responsibility for the statements expressed by the authors here in. Also they do not guarantee, warrant or endorse any product or service advertised in the journal.