Effect of Omega-3 Fatty Acid Supplementation on Cellular Lipid Profile: A Case Series

Abstract

Objective

The purpose of this report is to describe changes in the cellular lipid profile of participants following 120 days of omega-3 fatty acid supplementation.

Methods

Six participants received a non-gastric acid-resistant omega-3 fatty acid supplement, with dosages personalized based on preintervention red blood cell (RBC) omega-6 to omega-3 ratios. Blood samples were analyzed pre- and postintervention to determine changes in RBC lipid profiles.

Results

Six participants who were either fully or partially compliant with the supplementation showed a mean reduction of 41.2% in their RBC omega-6 to omega-3 ratio, with 2 participants achieving a ratio of 4:1 or lower.

Conclusion

Several of the compliant participants with Omega-3 fatty acid supplementation recorded a reduction in the omega-6 to omega-3 ratio in RBC lipid profiles.