Epidemiología de la infección por rinovirus/enterovirus en pacientes hospitalizados

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Revista clinica espanola Pub Date : 2025-12-01 Epub Date: 2025-11-21 DOI:10.1016/j.rce.2025.502391

B. Lopez-Villalba , L. Tejedor-Cantero , M. Toquero-Asensio , V. Fernández-Espinilla , C. Hernán-García , S. Rojo-Rello , C. Prada-García , J.M. Eiros-Bouza , J. Castrodeza-Sanz

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引用次数: 0

Abstract

Background and objective

Rhinovirus/enterovirus (RV/EV), commonly known for causing mild colds, has emerged as a significant cause of hospitalization. The objective of the study is to analyze the characteristics of patients hospitalized for viral respiratory infections, with an emphasis on RV/EV.

Methodology

This retrospective study was conducted between 2019 and 2022 at the University Clinical Hospital of Valladolid. Data from 1,528 cases were analyzed, sourced from medical records and microbiological tests (Biofire Respiratory y NxTAG respiratory panel).

Results

RV/EV was the most common respiratory virus (42.6%). There was a slight predominance of cases in males. 44.6% had a hospital stay of 2 to 7 days. The average hospitalization incidence was 3 per 1,000 adults per year. Children aged 0 to 15 years are at higher risk of RV/EV infection, with a 1.5 times higher probability in single infections (OR 1.496; 95% CI 1.147-1.952; p = 0.003), 7 times in coinfections with other respiratory viruses (OR 6.887; 95% CI 3.928-12.045; p< 0.01), and 8 times in coinfections with RSV (OR 8.580; 95% CI 3.866-19.041; p< 0.01). RV/EV is associated with a higher risk of asthma exacerbation (OR 2.545; 95% CI 1.336-4.851; p = 0.005) and COPD exacerbation (OR 1.781; 95% CI 1.022-3.103; p = 0.042), but a lower probability of bronchiolitis (OR 0.236; 95% CI 0.117-0.474; p< 0.01).

Conclusion

This study identifies RV/EV as the main respiratory virus in hospitalized patients, with a greater impact on those under 15 years and over 60 years. Seasonality and the coexistence of multiple viruses complicate its behaviour. These findings underscore the importance of preventive strategies and the need for continued research on its health impact.

查看原文本刊更多论文

住院患者中鼻病毒/肠道病毒感染的流行病学

背景和目的通常以引起轻度感冒而闻名的疱疹病毒/肠道病毒（RV/EV）已成为住院治疗的重要原因。本研究的目的是分析病毒性呼吸道感染住院患者的特征，重点是RV/EV。该回顾性研究于2019年至2022年在巴利亚多利德大学临床医院进行。分析了1,528例病例的数据，这些数据来自医疗记录和微生物测试（Biofire Respiratory y NxTAG呼吸面板）。结果rv /EV是最常见的呼吸道病毒（42.6%）。病例中男性略占优势。44.6%住院时间为2 ~ 7天。每年平均住院率为千分之三。0 ~ 15岁儿童感染RV/EV的风险较高，单次感染的概率为1.5倍（OR 1.496; 95% CI 1.147 ~ 1.952; p = 0.003），与其他呼吸道病毒共感染的概率为7倍（OR 6.887; 95% CI 3.928 ~ 12.045; p< 0.01），与RSV共感染的概率为8倍（OR 8.580; 95% CI 3.866 ~ 19.041; p< 0.01）。RV/EV与较高的哮喘加重风险（OR 2.545; 95% CI 1.336-4.851; p = 0.005）和COPD加重风险（OR 1.781; 95% CI 1.022-3.103; p = 0.042）相关，但与较低的毛细支气管炎风险相关（OR 0.236; 95% CI 0.117-0.474; p< 0.01）。结论本研究确定RV/EV是住院患者中主要的呼吸道病毒，在15岁以下和60岁以上患者中影响较大。季节性和多种病毒的共存使其行为复杂化。这些发现强调了预防战略的重要性以及继续研究其对健康影响的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista clinica espanola 医学-医学：内科

CiteScore

4.40

自引率

6.90%

发文量

审稿时长

28 days

期刊介绍： Revista Clínica Española published its first issue in 1940 and is the body of expression of the Spanish Society of Internal Medicine (SEMI). The journal fully endorses the goals of updating knowledge and facilitating the acquisition of key developments in internal medicine applied to clinical practice. Revista Clínica Española is subject to a thorough double blind review of the received articles written in Spanish or English. Nine issues are published each year, including mostly originals, reviews and consensus documents.