Bioinformatics applications in pharmacogenomics: towards personalized medicine

IF 2.7 3区生物学 Q2 GENETICS & HEREDITY

Gene Pub Date : 2026-02-10 Epub Date: 2025-12-04 DOI:10.1016/j.gene.2025.149935

Nabil Zaid , Lamyaa Benchikhi , Banacer Himmi , Hassan Ghazal

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Abstract

Pharmacogenomics investigates how genetic variation influences individual responses to drug therapy and aims to optimize treatment outcomes through personalized approaches. Bioinformatics plays a foundational role in this field, enabling the processing, annotation, and interpretation of complex genomic and multi-omics datasets. This review explores the current landscape of bioinformatics in pharmacogenomics, including key databases, variant analysis tools, and artificial intelligence-driven predictive models. It also discusses the integration of multi-omics data, real-world clinical applications, and the regulatory and ethical frameworks supporting clinical implementation. Finally, the role of pharmacogenomics in drug discovery and development is highlighted, illustrating how genetic insights contribute to target identification, trial design, and drug repurposing. Together, these components form the computational backbone of precision medicine and are essential for translating genomic knowledge into actionable, patient-centered care.

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生物信息学在药物基因组学中的应用：走向个性化医疗

药物基因组学研究遗传变异如何影响个体对药物治疗的反应，旨在通过个性化方法优化治疗结果。生物信息学在这一领域起着基础作用，使复杂的基因组和多组学数据集的处理、注释和解释成为可能。本文综述了药物基因组学中生物信息学的现状，包括关键数据库、变异分析工具和人工智能驱动的预测模型。它还讨论了多组学数据的集成，现实世界的临床应用，以及支持临床实施的监管和伦理框架。最后，强调了药物基因组学在药物发现和开发中的作用，说明了遗传见解如何有助于目标识别，试验设计和药物再利用。这些组成部分共同构成了精准医疗的计算支柱，对于将基因组知识转化为可操作的、以患者为中心的护理至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene 生物-遗传学

CiteScore

6.10

自引率

2.90%

发文量

718

审稿时长

42 days

期刊介绍： Gene publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses.