Clinically significant delayed gastric emptying after multivisceral resection for retroperitoneal sarcoma: A retrospective cohort study

IF 2.1 4区医学 Q3 ONCOLOGY

Surgical Oncology-Oxford Pub Date : 2026-02-01 Epub Date: 2025-12-02 DOI:10.1016/j.suronc.2025.102336

Dorian Yarih Garcia-Ortega , Luis Antonio Bonilla-Salado , Ana Paulina Meléndez-Fernández , Sylvia Veronica Villavicencio-Valencia , Diyitzia Rosario Irineo-Cerecedo , Cherilynn Martinez-Valdovinos , David Aarón Bujanda-Sandoval , Kuauhyama Luna-Ortiz

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引用次数: 0

Abstract

Background

Delayed gastric emptying (DGE) is an underrecognized but clinically impactful complication following multivisceral resection (MVR) for retroperitoneal sarcoma (RPS). This study aimed to determine the incidence, risk factors, and postoperative morbidity of clinically significant DGE in a Latin American tertiary referral sarcoma center.

Methods

We conducted a retrospective cohort study of adult patients with primary or recurrent RPS who underwent MVR between January 2020 and December 2024. DGE was defined and graded according to ISGPS criteria, with grades B–C considered clinically significant. Multivariable logistic regression identified independent predictors for DGE. Clinical outcomes were compared by DGE status.

Results

Among 142 patients who underwent MVR, the incidence of clinically significant DGE was 8.6 %. Independent risk factors included tumor size >22 cm (OR 2.25; 95 % CI 1.12–4.50; p = 0.023), dedifferentiated liposarcoma histology (OR 3.52; 95 % CI 1.12–11.01; p = 0.031), and multifocal disease (OR 2.78; 95 % CI 1.03–7.49; p = 0.044). DGE was associated with a prolonged hospital stay (22 vs. 10.5 days, p < 0.001) and a higher rate of ICU admission (9.3 % vs. 2.7 %, p = 0.034). No significant associations were found with major complications or reoperation.

Conclusions

Clinically significant DGE is an infrequent but high-impact complication after MVR for RPS. Tumor-related features such as large size, high-grade histology, and multifocality contribute to its development. Early identification and standardized perioperative strategies may help reduce the incidence and clinical burden of this condition. These findings provide essential data from a historically underrepresented region and support efforts to optimize postoperative recovery in complex sarcoma surgery.

查看原文本刊更多论文

腹膜后肉瘤多脏器切除后显著的胃排空延迟：一项回顾性队列研究。

背景：胃排空延迟（DGE）是腹膜后肉瘤（RPS）多脏器切除术（MVR）后未被充分认识但具有临床影响的并发症。本研究旨在确定拉丁美洲三级转诊肉瘤中心临床显著DGE的发病率、危险因素和术后发病率。方法：我们对2020年1月至2024年12月期间接受MVR治疗的原发性或复发性RPS成年患者进行了回顾性队列研究。DGE根据ISGPS标准定义和分级，B-C级被认为具有临床意义。多变量逻辑回归确定了DGE的独立预测因子。根据DGE状态比较临床结果。结果：142例MVR患者中，有临床意义的DGE发生率为8.6%。独立危险因素包括肿瘤大小>22 cm （OR 2.25; 95% CI 1.12-4.50; p = 0.023）、去分化脂肪肉瘤组织学（OR 3.52; 95% CI 1.12-11.01; p = 0.031）和多灶性疾病（OR 2.78; 95% CI 1.03-7.49; p = 0.044）。DGE与延长住院时间相关（22天vs 10.5天）。结论：临床显著的DGE是RPS MVR术后少见但影响较大的并发症。肿瘤的相关特征，如体积大、组织学分级高、多灶性是其发展的原因。早期识别和标准化的围手术期策略可能有助于减少这种情况的发生率和临床负担。这些发现为历史上代表性不足的地区提供了重要数据，并支持优化复杂肉瘤手术术后恢复的努力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgical Oncology-Oxford 医学-外科

CiteScore

4.50

自引率

0.00%

发文量

169

审稿时长

38 days

期刊介绍： Surgical Oncology is a peer reviewed journal publishing review articles that contribute to the advancement of knowledge in surgical oncology and related fields of interest. Articles represent a spectrum of current technology in oncology research as well as those concerning clinical trials, surgical technique, methods of investigation and patient evaluation. Surgical Oncology publishes comprehensive Reviews that examine individual topics in considerable detail, in addition to editorials and commentaries which focus on selected papers. The journal also publishes special issues which explore topics of interest to surgical oncologists in great detail - outlining recent advancements and providing readers with the most up to date information.