Skin cancer in inflammatory arthritis: should we advise screening?

IF 29.5 1区医学 Q1 RHEUMATOLOGY

Lancet Rheumatology Pub Date : 2026-02-01 Epub Date: 2025-12-01 DOI:10.1016/S2665-9913(25)00312-1

Konstantinos D Vassilakis MD , Kyriaki Lampadaki MD , Elena Nikiphorou MD PhD , George E Fragoulis MD PhD

引用次数: 0

Abstract

Inflammatory arthritis refers to a group of related clinical entities marked mainly by inflammation of the joints, the spine, or both. Rheumatoid arthritis and spondyloarthritis (which includes psoriatic arthritis and axial spondyloarthritis) are the most common forms of inflammatory arthritis. As more studies are conducted, there are accumulating data suggesting the elevated risk of skin cancer, including both melanoma and non-melanoma skin cancer, in inflammatory arthritis compared with the general population. In this context, the question of whether screening for skin cancer should be recommended in individuals with inflammatory arthritis is more relevant than ever. In this Review, we discuss the current knowledge on the risk and possible associations of melanoma and non-melanoma skin cancer in inflammatory arthritis with the aim of raising awareness within the rheumatology community about the risk of skin cancer, screening, and guidance.

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炎性关节炎中的皮肤癌：我们应该建议筛查吗？

炎症性关节炎是指一组以关节、脊柱或两者的炎症为主要标志的相关临床实体。类风湿性关节炎和脊椎关节炎（包括银屑病关节炎和轴性脊椎关节炎）是炎症性关节炎最常见的形式。随着越来越多的研究进行，越来越多的数据表明，与普通人群相比，炎症性关节炎患者患皮肤癌（包括黑色素瘤和非黑色素瘤皮肤癌）的风险更高。在这种情况下，是否应该推荐炎症性关节炎患者进行皮肤癌筛查的问题比以往任何时候都更有意义。在这篇综述中，我们讨论了目前关于黑色素瘤和非黑色素瘤皮肤癌在炎症性关节炎中的风险和可能的关联的知识，目的是提高风湿病学界对皮肤癌风险、筛查和指导的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lancet Rheumatology RHEUMATOLOGY-

CiteScore

34.70

自引率

3.10%

发文量

279

期刊介绍： The Lancet Rheumatology, an independent journal, is dedicated to publishing content relevant to rheumatology specialists worldwide. It focuses on studies that advance clinical practice, challenge existing norms, and advocate for changes in health policy. The journal covers clinical research, particularly clinical trials, expert reviews, and thought-provoking commentary on the diagnosis, classification, management, and prevention of rheumatic diseases, including arthritis, musculoskeletal disorders, connective tissue diseases, and immune system disorders. Additionally, it publishes high-quality translational studies supported by robust clinical data, prioritizing those that identify potential new therapeutic targets, advance precision medicine efforts, or directly contribute to future clinical trials. With its strong clinical orientation, The Lancet Rheumatology serves as an independent voice for the rheumatology community, advocating strongly for the enhancement of patients' lives affected by rheumatic diseases worldwide.