A comparative cohort study of epilepsy in children in Greenland and Denmark.

IF 1.7 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Journal of Circumpolar Health Pub Date : 2025-12-31 Epub Date: 2025-12-04 DOI:10.1080/22423982.2025.2593698

Jacqueline M Mistry, Bolette Søborg, Anders Koch, Mikael Andersson, Maria J Miranda, Malene L Børresen

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Abstract

Few studies on epilepsy in Greenlandic children exist, and the results are inconsistent. The objective of this study was to estimate the burden of epilepsy in children in Greenland and Denmark and secondly to identify demographic risk factors. Third, the risk of epilepsy after febrile seizures should be estimated. A register-based cohort study of all children in Greenland and Denmark aged 0-15 years from 1987 to 2014 was conducted. Using the Greenlandic and Danish National Patient Register, cases were identified and coupled to demographics through the Civil Registration System. The outcomes were incidence rates (IR) per 100,000 person-years (PY) and hazard ratios (HR).The study showed an epilepsy IR of 150/100,000 PY (139-162) in Greenland and 110/100,000PY (108-111) in Denmark and an HR of 1.34. The IRs were very high in the first years of life. A significantly higher HR was found for male sex, Inuit ethnicity in Greenland and habitation in Greenland outside of the capital. The risk of epilepsy after the diagnosis of febrile seizures was almost doubled in Greenland compared with Denmark.

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格陵兰和丹麦儿童癫痫的比较队列研究。

关于格陵兰儿童癫痫的研究很少，结果也不一致。本研究的目的是估计格陵兰和丹麦儿童的癫痫负担，其次是确定人口危险因素。第三，要估计热性惊厥后癫痫的危险性。对1987年至2014年格陵兰和丹麦0-15岁的所有儿童进行了一项基于登记册的队列研究。使用格陵兰和丹麦国家患者登记册，通过民事登记系统确定病例并与人口统计学相结合。结果是发病率（IR）每10万人年（PY）和风险比（HR）。该研究显示，格陵兰的癫痫IR为150/100,000 PY(139-162)，丹麦为110/100,000PY (108-111)， HR为1.34。在生命的最初几年里，IRs非常高。男性、格陵兰岛因纽特人以及居住在格陵兰岛首都以外地区的人的人力资源比男性高得多。在格陵兰，诊断为热性癫痫发作后患癫痫的风险几乎是丹麦的两倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Circumpolar Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

2.10

自引率

15.40%

发文量

审稿时长

6-12 weeks

期刊介绍： The International Journal of Circumpolar Health is published by Taylor & Francis on behalf of the Circumpolar Health Research Network [CircHNet]. The journal follows the tradition initiated by its predecessor, Arctic Medical Research. The journal specializes in circumpolar health. It provides a forum for many disciplines, including the biomedical sciences, social sciences, and humanities as they relate to human health in high latitude environments. The journal has a particular interest in the health of indigenous peoples. It is a vehicle for dissemination and exchange of knowledge among researchers, policy makers, practitioners, and those they serve. International Journal of Circumpolar Health welcomes Original Research Articles, Review Articles, Short Communications, Book Reviews, Dissertation Summaries, History and Biography, Clinical Case Reports, Public Health Practice, Conference and Workshop Reports, and Letters to the Editor.