Consistency of outcomes of studies on rectal cancer from the NCDB and SEER databases: A systematic review

IF 2.3 3区医学 Q1 SURGERY

American journal of surgery Pub Date : 2026-02-01 Epub Date: 2025-11-20 DOI:10.1016/j.amjsurg.2025.116728

Justin Dourado , Matthew Bilotti , Sameh Hany Emile , Anjelli Wignakumar , Cameron Perrone , Spencer Barnes , Nir Horesh , Steven D. Wexner

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引用次数: 0

Abstract

Introduction

The National Cancer Database (NCDB) and the Surveillance, Epidemiology, and End Results (SEER) Program are major national cancer databases. While widely used, it is unclear if studies from each yield consistent conclusions on similar questions. This study compared findings from NCDB and SEER studies on rectal adenocarcinoma care to assess concordance.

Methods

This PRISMA-compliant systematic review included studies evaluating rectal adenocarcinoma care using NCDB or SEER data. The main outcome was concordance or discordance between studies with overlapping topics.

Results

Of 310 screened studies, 30 addressed overlapping questions, with nine areas of overlap, and major disagreements in four. SEER studies showed a survival benefit of neoadjuvant radiation therapy (NRT) in mucinous adenocarcinoma, unlike NCDB studies. Other differences involved adjuvant therapy for stage T3N0 and stage II disease, and lymph node yield cutoffs.

Conclusion

Most NCDB and SEER study conclusions were consistent, with discrepancies limited to controversial areas.

Abstract Image

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NCDB和SEER数据库中直肠癌研究结果的一致性：一项系统综述。

国家癌症数据库（NCDB）和监测、流行病学和最终结果（SEER）计划是主要的国家癌症数据库。虽然被广泛使用，但目前尚不清楚两项研究是否在类似问题上得出一致的结论。本研究比较了NCDB和SEER对直肠腺癌护理的研究结果，以评估一致性。方法：这项符合prisma标准的系统综述纳入了使用NCDB或SEER数据评估直肠腺癌治疗的研究。主要结果是有重叠主题的研究之间的一致性或不一致性。结果：在310项筛选研究中，30项涉及重叠问题，9个领域重叠，4个领域存在重大分歧。与NCDB研究不同，SEER研究显示新辅助放射治疗（NRT）在粘液腺癌中的生存获益。其他差异包括T3N0期和II期疾病的辅助治疗，以及淋巴结产量截止。结论：大多数NCDB和SEER研究结论是一致的，差异仅限于有争议的领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of surgery 医学-外科

CiteScore

5.00

自引率

6.70%

发文量

570

审稿时长

56 days

期刊介绍： The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.