Mixtures and dilutions of commercial solutions for oral drops: What happens in these cocktails?

IF 2.1 4区医学 Q3 PHARMACOLOGY & PHARMACY

Therapie Pub Date : 2026-07-01 Epub Date: 2025-11-17 DOI:10.1016/j.therap.2025.11.002

Caroline Castera-Ducros, Romain Paoli-Lombardo, Ikram Zaddam, Cyril Fersing, Charleric Bornet, Patrice Vanelle, Pascal Rathelot, Christophe Curti

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引用次数: 0

Abstract

Background

Physicochemical incompatibilities of parenteral drugs are frequently studied and reported, but are rarely documented for liquid oral drugs. However, in clinical practices, nurses may perform mixtures of several liquid oral formulations. Although such practices are not recommended, there is a lack of scientific evidence to support this statement.

Objective

We aimed to study potential incompatibilities of the most dispensed commercial liquid oral formulations in a psychiatric ward.

Methods

First, a bibliographic analysis was performed. Then, 1:1 mixtures of one commercial liquid specialty and tap water and 1:1:1 mixtures of two commercial formulations and water were realized and controlled both visually and analytically. When a precipitate was formed, the mixture was considered incompatible.

Results

A table of oral liquid drug incompatibilities was compiled, and the need for pharmaceutical expertise on this subject was discussed.

Conclusion

This work is the first report of oral liquid drugs’ physicochemical incompatibilities and can lead to an improvement in clinical practices.

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商业口服滴剂溶液的混合物和稀释剂：在这些鸡尾酒中发生了什么？

背景：肠外药物的物理化学不相容性经常被研究和报道，但很少有关于口服液体药物的文献记录。然而，在临床实践中，护士可能会使用几种液体口服配方的混合物。虽然不推荐这样的做法，但缺乏科学证据来支持这一说法。目的：我们旨在研究在精神科病房配药最多的商业口服液制剂的潜在不相容性。方法：首先进行文献分析。然后，实现了一种商品专用液体与自来水1:1的混合，以及两种商品配方与水1:1:1的混合，并进行了可视化和分析控制。当沉淀形成时，混合物被认为是不相容的。结果：编制了口服液药物不配伍表，并讨论了对这一课题的药学专业知识的需求。结论：本文首次报道了口服液类药物的理化不相容性，对临床应用具有一定的指导意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapie 医学-药学

CiteScore

3.50

自引率

7.70%

发文量

132

审稿时长

57 days

期刊介绍： Thérapie is a peer-reviewed journal devoted to Clinical Pharmacology, Therapeutics, Pharmacokinetics, Pharmacovigilance, Addictovigilance, Social Pharmacology, Pharmacoepidemiology, Pharmacoeconomics and Evidence-Based-Medicine. Thérapie publishes in French or in English original articles, general reviews, letters to the editor reporting original findings, correspondence relating to articles or letters published in the Journal, short articles, editorials on up-to-date topics, Pharmacovigilance or Addictovigilance reports that follow the French "guidelines" concerning good practice in pharmacovigilance publications. The journal also publishes thematic issues on topical subject. The journal is indexed in the main international data bases and notably in: Biosis Previews/Biological Abstracts, Embase/Excerpta Medica, Medline/Index Medicus, Science Citation Index.