Efficacy and Safety of Intravesical Electrical Stimulation for Underactive Bladder: A Meta-Analysis and Systematic Review

IF 3.7 3区医学 Q2 CLINICAL NEUROLOGY

Neuromodulation Pub Date : 2026-10-01 Epub Date: 2025-12-03 DOI:10.1016/j.neurom.2025.10.059

Hao Yu MD, Zheng Duan MD, Jiayin Sun MD, Zongyao Fan MD, PhD, Junjie Zhang MD, PhD, Zhengsen Chen MD, Pengyu Wang MD, Zhongqing Wei MD, PhD

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引用次数: 0

Abstract

Background

Underactive bladder (UAB) can lead to urinary retention and kidney damage, severely affecting patients' health. Currently, there are insufficient effective treatments. Some studies suggest that intravesical electrical stimulation (IVES) may relieve symptoms in patients with UAB, but its efficacy remains uncertain. This study aims to explore the effectiveness of IVES and provide guidance for clinical decision-making.

Materials and Methods

On the basis of the search keywords, we searched PubMed, Web of Science, Cochrane Library, and Embase data bases up to January 20, 2025 and screened studies according to the inclusion and exclusion criteria. We extracted urodynamic and symptom assessment indicators from eligible studies, calculated pooled mean differences (MDs) and 95% CIs, and validated results using subgroup and sensitivity analyses. Publication bias was assessed using funnel plots and Egger's test.

Results

Six studies with 310 patients were included. The pooled results showed postvoid residual urine volume (PVR) had a significant improvement (MD = −108.7 mL, 95% CI: −177.69; −39.71). The secondary outcomes, including voided volume, urine flow rate, voiding efficiency, and 24-hour clean intermittent catheterization first sensation capacity, were assessed. Among these, both voided volume (MD = 86.66 mL, 95% CI: 1.56; 171.77) and voiding efficiency (MD = 30.72%, 95% CI: 21.95; 39.49) showed improvement in patients who received IVES compared with those who did not. The most common adverse event was urinary tract infection, with no severe adverse events reported.

Conclusions

IVES might be effective in reducing PVR, increasing voided volume, and improving voiding efficiency in patients with UAB, and is a safe, minimally invasive, and simple treatment option. It can be considered as a treatment choice for UAB, although this conclusion still needs to be verified by large-scale and high-quality clinical studies.

International Prospective Register of Systematic Reviews Registered ID

CRD420251011794

查看原文本刊更多论文

膀胱内电刺激治疗膀胱活动不足的有效性和安全性：荟萃分析和系统评价。

背景：膀胱活动不足可导致尿潴留和肾脏损害，严重影响患者的健康。目前，缺乏有效的治疗方法。一些研究表明，膀胱内电刺激（IVES）可能缓解UAB患者的症状，但其疗效仍不确定。本研究旨在探讨IVES的有效性，为临床决策提供指导。材料和方法：根据检索关键词，检索截至2025年1月20日的PubMed、Web of Science、Cochrane Library和Embase数据库，根据纳入和排除标准筛选研究。我们从符合条件的研究中提取尿动力学和症状评估指标，计算汇总平均差异（MDs）和95% ci，并通过亚组和敏感性分析验证结果。采用漏斗图和Egger检验评估发表偏倚。结果：纳入6项研究，共310例患者。综合结果显示，空后残留尿量（PVR）有显著改善（MD = -108.7 mL, 95% CI: -177.69; -39.71）。次要结果包括排尿量、尿流率、排尿效率和24小时清洁间歇导尿第一感觉能力。其中，接受IVES的患者排尿量（MD = 86.66 mL, 95% CI: 1.56; 171.77）和排尿效率（MD = 30.72%, 95% CI: 21.95; 39.49）均较未接受IVES的患者有所改善。最常见的不良事件是尿路感染，无严重不良事件报道。结论：ivs可有效降低UAB患者PVR，增加排尿量，提高排尿效率，是一种安全、微创、简便的治疗方法。它可以被认为是UAB的一种治疗选择，尽管这一结论仍需要大规模、高质量的临床研究来验证。国际前瞻性系统评价注册id: crd420251011794。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuromodulation 医学-临床神经学

CiteScore

6.40

自引率

3.60%

发文量

978

审稿时长

54 days

期刊介绍： Neuromodulation: Technology at the Neural Interface is the preeminent journal in the area of neuromodulation, providing our readership with the state of the art clinical, translational, and basic science research in the field. For clinicians, engineers, scientists and members of the biotechnology industry alike, Neuromodulation provides timely and rigorously peer-reviewed articles on the technology, science, and clinical application of devices that interface with the nervous system to treat disease and improve function.