{"title":"Effects of tailored exercise on glycemic and nutritional outcomes in diabetic patients with colorectal cancer and on chemotherapy.","authors":"Lin Yang, Xian-Ping Liu, Xiao-Meng Deng","doi":"10.4239/wjd.v16.i11.111008","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) is the third most diagnosed malignancy worldwide and a frequent comorbidity among these patients is type 2 diabetes mellitus (T2DM). The coexistence of these conditions poses significant challenges to glycemic management, particularly during chemotherapy.</p><p><strong>Aim: </strong>To assess the effects of individualized exercise training (IET) on glycemic control and nutritional status in patients with T2DM undergoing chemotherapy for CRC.</p><p><strong>Methods: </strong>In this retrospective study, clinical data from 245 patients with T2DM and on chemotherapy for CRC between November 2023 and December 2024 were analyzed. Patients were stratified into two groups according to their treatment regimens: The standard care (SC) group (<i>n</i> = 111), which received conventional chemotherapy and diabetes management, and an IET group (<i>n</i> = 134), which received additional personalized exercise interventions alongside SC. Parameters assessed included fasting plasma glucose, glycosylated hemoglobin, glycemic variability indices, nutritional biomarkers, markers of intestinal permeability, and adverse events.</p><p><strong>Results: </strong>Patients in the IET group demonstrated significant improvements in glycemic control, nutritional biomarkers, and glycemic variability (all <i>P</i> < 0.05), compared with the SC group. The markers of intestinal permeability also improved significantly in the IET group (<i>P</i> < 0.05). Meanwhile, no statistically significant difference in the incidence of adverse events was found between the two groups (<i>P</i> > 0.05). These findings suggest that individualized exercise interventions can enhance metabolic, nutritional, and gastrointestinal outcomes without increasing treatment-related risks.</p><p><strong>Conclusion: </strong>Personalized exercise training may offer clinically meaningful benefits in glycemic regulation and nutritional status for patients with T2DM and on chemotherapy for CRC.</p>","PeriodicalId":48607,"journal":{"name":"World Journal of Diabetes","volume":"16 11","pages":"111008"},"PeriodicalIF":5.1000,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12666341/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Diabetes","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4239/wjd.v16.i11.111008","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
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Abstract
Background: Colorectal cancer (CRC) is the third most diagnosed malignancy worldwide and a frequent comorbidity among these patients is type 2 diabetes mellitus (T2DM). The coexistence of these conditions poses significant challenges to glycemic management, particularly during chemotherapy.
Aim: To assess the effects of individualized exercise training (IET) on glycemic control and nutritional status in patients with T2DM undergoing chemotherapy for CRC.
Methods: In this retrospective study, clinical data from 245 patients with T2DM and on chemotherapy for CRC between November 2023 and December 2024 were analyzed. Patients were stratified into two groups according to their treatment regimens: The standard care (SC) group (n = 111), which received conventional chemotherapy and diabetes management, and an IET group (n = 134), which received additional personalized exercise interventions alongside SC. Parameters assessed included fasting plasma glucose, glycosylated hemoglobin, glycemic variability indices, nutritional biomarkers, markers of intestinal permeability, and adverse events.
Results: Patients in the IET group demonstrated significant improvements in glycemic control, nutritional biomarkers, and glycemic variability (all P < 0.05), compared with the SC group. The markers of intestinal permeability also improved significantly in the IET group (P < 0.05). Meanwhile, no statistically significant difference in the incidence of adverse events was found between the two groups (P > 0.05). These findings suggest that individualized exercise interventions can enhance metabolic, nutritional, and gastrointestinal outcomes without increasing treatment-related risks.
Conclusion: Personalized exercise training may offer clinically meaningful benefits in glycemic regulation and nutritional status for patients with T2DM and on chemotherapy for CRC.
期刊介绍：
The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.
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