Role of oral microbiome in modulating immune response in oral cancer development. a systematic review.

IF 4.3 3区医学 Q1 PATHOLOGY

Expert Review of Molecular Diagnostics Pub Date : 2025-12-01 Epub Date: 2025-12-04 DOI:10.1080/14737159.2025.2599227

Rezhat Abbas, Nazifa Javaid

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引用次数: 0

Abstract

Background: Oral squamous cell carcinoma, the most common head and neck cancer, is characterized by aggressive invasion, frequent lymph node metastasis, and high recurrence.

Objective: This review explores the role of microbial dysbiosis in shaping the immune landscape of oral squamous cell carcinoma. It aims to identify key microbial taxa altered in Oral squamous cell carcinoma, examine the immunological pathways they influence, and assess their impact on tumor progression and immune evasion.

Methods: A comprehensive literature search was conducted across three major databases: PubMed, Scopus, and Embase. A total of 300 records were initially identified (PubMed: n = 68; Scopus: n = 63; Embase: n = 169). After screening and eligibility assessment, 17 studies meeting inclusion criteria were selected for final analysis.

Results: Fusobacterium was the most frequently enriched genus in Oral squamous cell carcinoma, followed by Peptostreptococcus, Prevotella, Porphyromonas, Campylobacter, Treponema, Capnocytophaga, and Dialister. Streptococcus was the most consistently depleted, along with Rothia, Veillonella, Leptotrichia, Capnocytophaga, and Neisseria.

Conclusion: Cancer remains a leading cause of death. Oral microbial dysbiosis, with loss of beneficial species and enrichment of pathogens, has been linked to oral cancer, but its mechanistic role remains hypothetical and requires validation.

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口腔微生物组在口腔癌发展中调节免疫反应的作用。系统回顾。

背景：口腔鳞状细胞癌是最常见的头颈部肿瘤，其特点是侵袭性强，淋巴结转移频繁，复发率高。目的：探讨微生物生态失调在口腔鳞状细胞癌免疫景观形成中的作用。目的是确定口腔鳞状细胞癌中发生改变的关键微生物群，研究它们影响的免疫途径，并评估它们对肿瘤进展和免疫逃避的影响。方法：在PubMed、Scopus和Embase三个主要数据库中进行全面的文献检索。最初共确定了300条记录（PubMed: n = 68; Scopus: n = 63; Embase: n = 169）。经过筛选和资格评估，17项符合纳入标准的研究入选最终分析。结果：口腔鳞状细胞癌中最常富集的属为梭杆菌，其次为胃链球菌、普雷沃氏菌、卟啉单胞菌、弯曲杆菌、密螺旋体、嗜糖菌和Dialister。链球菌与罗氏菌、细胞菌、纤毛菌、嗜碳细胞菌和奈瑟菌一起被持续耗尽。结论：癌症仍然是导致死亡的主要原因。口腔微生物生态失调，伴随着有益物种的丧失和病原体的富集，与口腔癌有关，但其机制作用仍然是假设的，需要验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Molecular Diagnostics 医学-病理学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting. Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy. Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.