Nitrofurantoin as a preferred first-line therapy for urinary tract infection: A comparison using urinary tract infection-specific antibiograms.

Bladder (San Francisco, Calif.) Pub Date : 2025-09-04 eCollection Date: 2025-01-01 DOI:10.14440/bladder.0018

Colby P Souders, Andrew Clark, Bonnie C Prokesch, Philippe E Zimmern

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Abstract

Background: Local antibiograms are a highly useful tool to guide empiric antibiotic therapy for a variety of infections.

Objectives: This study compares nitrofurantoin (NF) susceptibility in outpatient urine isolates using antibiogram data from two United States academic medical centers.

Methods: In this brief report, we compare antibiograms of urinary isolates from two distinct academic institutions-the University of Texas Southwestern (UTSW) in Dallas, Texas, and the University of Kansas Medical Center (KU) in Kansas City, Kansas-focusing on the most common uropathogens susceptible to NF to evaluate whether NF remains an appropriate first-line agent for uncomplicated cystitis.

Results: For the 2022 antibiogram, KU tested 5,524 urinary isolates and UTSW tested 2,530 urinary isolates. The susceptibility data were consistent across the two institutions, suggesting that NF can continue to be considered a first-line therapy for uncomplicated urinary tract infections in women.

Conclusion: This report highlights the importance of clinicians consulting their local antibiograms to inform empiric antibiotic therapy.

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呋喃妥因作为尿路感染的首选一线治疗：使用尿路感染特异性抗生素图的比较

背景：局部抗生素图是指导各种感染的经验性抗生素治疗的非常有用的工具。目的：本研究利用美国两个学术医疗中心的抗生素谱数据比较门诊尿分离物中呋喃妥因（NF）的敏感性。方法：在这篇简短的报告中，我们比较了两个不同的学术机构——德克萨斯州达拉斯的德克萨斯大学西南分校（UTSW）和堪萨斯州堪萨斯城的堪萨斯大学医学中心（KU）——泌尿系分离物的抗生素谱，重点关注最常见的对NF敏感的泌尿系病原体，以评估NF是否仍然是治疗无并发症膀胱炎的合适一线药物。结果：对于2022年抗生素谱，KU检测了5524个尿分离物，UTSW检测了2530个尿分离物。两家机构的易感性数据是一致的，这表明NF可以继续被认为是女性无并发症尿路感染的一线治疗方法。结论：本报告强调了临床医生咨询当地抗生素图以告知经验性抗生素治疗的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bladder (San Francisco, Calif.)

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