Late gadolinium enhancement in patients with and without autoimmune rheumatic diseases: “walking, we create the way”

IF 3.9 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology Pub Date : 2026-02-01 Epub Date: 2025-11-19 DOI:10.1016/j.ejrad.2025.112542

George Markousis-Mavrogenis , Alessia Pepe , Brittany N. Weber , Anne Hui Sze Kwong , Vassiliki Vartela , Monica Mukherjee , Juerg Schwitter , Sophie I. Mavrogeni

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引用次数: 0

Abstract

Myocardial fibrosis constitutes an important pathophysiologic and maladaptive process in the vast majority of cardiac diseases. Contemporary cardiologists are permitted a very nuanced glimpse of myocardial fibrosis by means of cardiovascular magnetic resonance imaging (CMR), and specifically late gadolinium enhancement (LGE) methods. These allow the evaluation of the presence, extent, and distribution of myocardial replacement fibrosis. An increasing amount of scientific evidence has demonstrated a significant role for LGE in the elucidation of cardiac pathophysiologic substrates in patients with autoimmune rheumatic diseases (ARDs) and cardiac involvement. However, whether existing methods for the evaluation of myocardial fibrosis can uniformly be extrapolated for use in patients with ARDs in their present form remains an important question. In this opinion paper, we provide a brief overview of the basic principles underlying LGE imaging, as well as the current status and challenges regarding its use in patients with and without ARDs.

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有或无自身免疫性风湿病患者的晚期钆增强：“行走，我们创造道路”。

心肌纤维化是绝大多数心脏疾病的重要病理生理和不适应过程。当代心脏病专家可以通过心血管磁共振成像（CMR），特别是晚期钆增强（LGE）方法，对心肌纤维化进行细致入微的观察。这些可以评估心肌替代性纤维化的存在、程度和分布。越来越多的科学证据表明，LGE在阐明自身免疫性风湿性疾病（ARDs）和心脏受累患者心脏病理生理底物方面发挥着重要作用。然而，是否现有的评估心肌纤维化的方法可以统一外推用于目前形式的ARDs患者仍然是一个重要的问题。在这篇观点文章中，我们简要概述了LGE成像的基本原理，以及LGE在ARDs和非ARDs患者中的应用现状和挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Radiology 医学-核医学

CiteScore

6.70

自引率

3.00%

发文量

398

审稿时长

42 days

期刊介绍： European Journal of Radiology is an international journal which aims to communicate to its readers, state-of-the-art information on imaging developments in the form of high quality original research articles and timely reviews on current developments in the field. Its audience includes clinicians at all levels of training including radiology trainees, newly qualified imaging specialists and the experienced radiologist. Its aim is to inform efficient, appropriate and evidence-based imaging practice to the benefit of patients worldwide.