Regulation of placental 15-hydroxyprostaglandin dehydrogenase activity by obstetric drugs

Kimihiro Nagai M.D., Tetsuji Tanaka M.D., Kenichi Tsuruta M.D., Norimasa Mori M.D.
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引用次数: 2

Abstract

The in vitro effects of obstetric drugs on 15-hydroxyprostaglandin dehydrogenase activity were investigated. Enzyme activity was inhibited by indomethacin, methylergometrine maleate, Solcoseryl®, conjugated estrogen and progesterone, and was activated only by isoxsuprine-HCL. Methylergometrine maleate and isoxsuprine-HCl, which have opposite functions on uterine muscle, also exerted contrary effects on enzyme activity. Inhibitory and stimulatory effects of these drugs suggested that they could directly regulate uterine activity and also indirectly influence the uterus due to their effects on prostaglandin catabolism in vivo.

产科药物对胎盘15-羟基前列腺素脱氢酶活性的调节作用
探讨产科药物对体外15-羟基前列腺素脱氢酶活性的影响。吲哚美辛、马来酸甲麦角新碱、索克瑟利、偶联雌激素和孕酮对酶活性均有抑制作用,仅异苏嘌呤-盐酸能激活酶活性。对子宫肌具有相反作用的马来酸甲麦角新碱和盐酸异苏嘌呤对子宫肌酶活性的影响也相反。这些药物的抑制和刺激作用表明,它们可以直接调节子宫活动,也可以通过对体内前列腺素分解代谢的作用间接影响子宫。
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