IL17 genetic variants impact the response and safety of TNFi treatment in rheumatoid arthritis patients from Bahia, Brazil

IF 2.7 3区生物学 Q2 GENETICS & HEREDITY

Gene Pub Date : 2026-02-05 Epub Date: 2025-11-20 DOI:10.1016/j.gene.2025.149910

Lilian de Sá Garcia Landeiro , Pedro Augusto Silva dos Santos Rodrigues , Almirane Lima de Oliveira , Katarina Mattos Brandão , Laryssa Cardoso Calmon , João Victor Andrade Cruz , Mailane dos Anjos Silva , Bruna Ramos Tosta , Ingrid de Marins de Almeida , João Locke Ferreira de Araújo , Thamara Miranda Barbosa dos Santos , Milca de Jesus Silva , Gabriela Pimentel Pinheiro das Chagas , Álvaro Augusto Souza da Cruz Filho , Camila Alexandrina Viana de Figueirêdo , Pablo de Moura Santos , Ryan dos Santos Costa

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引用次数: 0

Abstract

Objective

Rheumatoid arthritis (RA) is a chronic inflammatory disease that can lead to progressive disability. TNF inhibitors (TNFi) have shown promise in improving disease progression and prognosis; however, only 60% to 70% of patients respond well. Genetic variations have been linked to this therapeutic failure. Genetic variants in the IL17 gene are associated with TNFi therapy responses and RA susceptibility, but few studies have explored this in the Brazilian population. This study assesses variants in the IL-17 pathway (rs763780, rs2275913, rs3819024) in RA patients undergoing TNFi treatment in Salvador, BA. Methods: A total of 497 individuals (294 RA patients, 203 healthy controls) were included. Plasma levels of IL-17, IL-1β, TNF, and other cytokines were measured in a subpopulation. Meta-analysis of published studies was conducted to consolidate associations between IL and 17 variants and RA susceptibility. Results: No significant associations were found between SNVs and RA susceptibility in the cohort, while the meta-analysis revealed protective and risk associations. The rs3819024-G allele was associated with improved TNFi response, particularly in infliximab users, whereas rs2275913-AA carriers had higher risk of treatment.

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IL17基因变异影响TNFi治疗在巴西巴伊亚的类风湿关节炎患者中的疗效和安全性

目的类风湿性关节炎（RA）是一种慢性炎症性疾病，可导致进行性残疾。TNF抑制剂（TNFi）已显示出改善疾病进展和预后的希望；然而，只有60%至70%的患者反应良好。遗传变异与这种治疗失败有关。IL17基因的遗传变异与TNFi治疗反应和RA易感性相关，但很少有研究在巴西人群中探讨这一点。本研究评估了萨尔瓦多，BA接受TNFi治疗的RA患者IL-17通路（rs763780, rs2275913, rs3819024）的变异。方法：共纳入497例（RA患者294例，健康对照203例）。在一个亚群中测量IL-17、IL-1β、TNF和其他细胞因子的血浆水平。对已发表的研究进行荟萃分析，以巩固IL和17种变体与RA易感性之间的关系。结果：在队列中，SNVs与RA易感性之间未发现显著关联，而荟萃分析显示了保护性和风险相关性。rs3819024-G等位基因与改善的TNFi反应相关，特别是在英夫利昔单抗使用者中，而rs2275913-AA携带者有更高的治疗风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene 生物-遗传学

CiteScore

6.10

自引率

2.90%

发文量

718

审稿时长

42 days

期刊介绍： Gene publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses.