A binary prototype for time-series surveillance and intervention

IF 2.4 3区 医学 Q2 INFECTIOUS DISEASES
Epidemics Pub Date : 2025-12-01 Epub Date: 2025-11-11 DOI:10.1016/j.epidem.2025.100866
Jason Olejarz , Till Hoffmann , Alex Zapf , Douaa Mugahid , Ross Molinaro , Chadwick Brown , Artem Boltyenkov , Taras Dudykevych , Ankit Gupta , Marc Lipsitch , Rifat Atun , Jukka-Pekka Onnela , Sarah Fortune , Rangarajan Sampath , Yonatan H. Grad
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引用次数: 0

Abstract

Despite much research on early detection of anomalies from surveillance data, a systematic framework for appropriately acting on these signals is lacking. We addressed this gap by formulating a hidden Markov-style model for time-series surveillance, where the system state, the observed data, and the decision rule are all binary. We incur a delayed cost, c, whenever the system is abnormal and no action is taken, or an immediate cost, k, with action, where k<c. If action costs are too high, then surveillance is detrimental, and intervention should never occur. If action costs are sufficiently low, then surveillance is detrimental, and intervention should always occur. Only when action costs are intermediate and surveillance costs are sufficiently low is surveillance beneficial. Our equations provide a framework for assessing which approach may apply under a range of scenarios and, if surveillance is warranted, facilitate methodical classification of intervention strategies. Our model thus offers a conceptual basis for designing real-world public health surveillance systems.
时间序列监视和干预的二进制原型
尽管对从监测数据中早期发现异常进行了大量研究,但缺乏对这些信号采取适当行动的系统框架。我们通过制定一个用于时间序列监视的隐马尔可夫式模型来解决这一差距,其中系统状态、观测数据和决策规则都是二进制的。当系统异常且不采取任何行动时,我们会产生延迟成本c,或者产生立即成本k,其中k<;c。如果行动成本太高,那么监督是有害的,干预就不应该发生。如果行动成本足够低,那么监督是有害的,应该始终进行干预。只有当行动成本处于中间水平,监督成本足够低时,监督才有益。我们的公式提供了一个框架,用于评估哪种方法可以在一系列情况下适用,如果有必要进行监测,则有助于对干预策略进行系统分类。因此,我们的模型为设计现实世界的公共卫生监测系统提供了概念基础。
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来源期刊
Epidemics
Epidemics INFECTIOUS DISEASES-
CiteScore
6.00
自引率
7.90%
发文量
92
审稿时长
140 days
期刊介绍: Epidemics publishes papers on infectious disease dynamics in the broadest sense. Its scope covers both within-host dynamics of infectious agents and dynamics at the population level, particularly the interaction between the two. Areas of emphasis include: spread, transmission, persistence, implications and population dynamics of infectious diseases; population and public health as well as policy aspects of control and prevention; dynamics at the individual level; interaction with the environment, ecology and evolution of infectious diseases, as well as population genetics of infectious agents.
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