Jason Olejarz , Till Hoffmann , Alex Zapf , Douaa Mugahid , Ross Molinaro , Chadwick Brown , Artem Boltyenkov , Taras Dudykevych , Ankit Gupta , Marc Lipsitch , Rifat Atun , Jukka-Pekka Onnela , Sarah Fortune , Rangarajan Sampath , Yonatan H. Grad
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引用次数: 0
Abstract
Despite much research on early detection of anomalies from surveillance data, a systematic framework for appropriately acting on these signals is lacking. We addressed this gap by formulating a hidden Markov-style model for time-series surveillance, where the system state, the observed data, and the decision rule are all binary. We incur a delayed cost, , whenever the system is abnormal and no action is taken, or an immediate cost, , with action, where . If action costs are too high, then surveillance is detrimental, and intervention should never occur. If action costs are sufficiently low, then surveillance is detrimental, and intervention should always occur. Only when action costs are intermediate and surveillance costs are sufficiently low is surveillance beneficial. Our equations provide a framework for assessing which approach may apply under a range of scenarios and, if surveillance is warranted, facilitate methodical classification of intervention strategies. Our model thus offers a conceptual basis for designing real-world public health surveillance systems.
期刊介绍:
Epidemics publishes papers on infectious disease dynamics in the broadest sense. Its scope covers both within-host dynamics of infectious agents and dynamics at the population level, particularly the interaction between the two. Areas of emphasis include: spread, transmission, persistence, implications and population dynamics of infectious diseases; population and public health as well as policy aspects of control and prevention; dynamics at the individual level; interaction with the environment, ecology and evolution of infectious diseases, as well as population genetics of infectious agents.