{"title":"Postinfectious Manifestation of Wilson's Disease in COVID-19 Presenting as Writer's Cramp: A Case Report.","authors":"Rajesh Verma, K P Arjun Bal, Rajarshi Chakraborty","doi":"10.4103/ant.ANT-D-24-00017","DOIUrl":null,"url":null,"abstract":"<p><p>Wilson's disease (WD) is a neurometabolic disorder of copper metabolism with varied neurological presentations. COVID-19 has been associated with a multitude of multisystemic involvement, especially nervous system due to direct involvement, systemic inflammation, and immune-mediated phenomena. Movement disorders, however, represent a small domain of COVID-19 illness. A 23-year-old male developed behavioral changes, writer's cramp, and other neuropsychiatric symptoms following a COVID-19 infection, leading to a diagnosis of WD. Examination revealed Kayser-Fleischer rings and brain imaging abnormalities. Diagnosis was confirmed by low ceruloplasmin levels, elevated 24 h urine copper, and genetic testing. This case highlights the postinfectious manifestations of WD and its rare presentation as a writer's cramp.</p>","PeriodicalId":93852,"journal":{"name":"Acta neurologica Taiwanica","volume":" ","pages":"248-250"},"PeriodicalIF":0.0000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta neurologica Taiwanica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ant.ANT-D-24-00017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/11/13 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Wilson's disease (WD) is a neurometabolic disorder of copper metabolism with varied neurological presentations. COVID-19 has been associated with a multitude of multisystemic involvement, especially nervous system due to direct involvement, systemic inflammation, and immune-mediated phenomena. Movement disorders, however, represent a small domain of COVID-19 illness. A 23-year-old male developed behavioral changes, writer's cramp, and other neuropsychiatric symptoms following a COVID-19 infection, leading to a diagnosis of WD. Examination revealed Kayser-Fleischer rings and brain imaging abnormalities. Diagnosis was confirmed by low ceruloplasmin levels, elevated 24 h urine copper, and genetic testing. This case highlights the postinfectious manifestations of WD and its rare presentation as a writer's cramp.
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