Metabolic command centers in Drosophila: how the fat body and oenocytes orchestrate immunity, reproduction, and aging

IF 5.5 1区农林科学 Q1 BIOLOGY

Current opinion in insect science Pub Date : 2026-02-01 Epub Date: 2025-11-09 DOI:10.1016/j.cois.2025.101459

Kerui Huang , Norbert Perrimon

引用次数: 0

Abstract

Energy storage and mobilization are fundamental to physiology and survival, yet their dysregulation drives obesity, diabetes, cancer, and age-related diseases. Drosophila melanogaster offers a tractable model for dissecting these pathways because its metabolic and endocrine circuits mirror those of vertebrates. In flies, the fat body functions like mammalian adipose and liver tissues, as it stores triacylglycerol and glycogen, produces lipoproteins, and serves as a major immune site. In addition, hepatocyte-like oenocytes direct lipid mobilization and trafficking during nutrient stress, synthesize cuticular hydrocarbons, and help regulate fertility and behavior. This review surveys discoveries enabled by single-cell genomics, metabolomics, and advanced genetics, with a focus on how the fat body and oenocytes integrate metabolism with reproduction, immunity, and aging.

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果蝇的代谢指挥中心：脂肪体和卵泡细胞如何协调免疫、繁殖和衰老。

能量储存和动员是生理和生存的基础，但它们的失调会导致肥胖、糖尿病、癌症和与年龄相关的疾病。黑腹果蝇提供了一个易于处理的模型来解剖这些通路，因为它的代谢和内分泌回路反映了脊椎动物的代谢和内分泌回路。在果蝇中，脂肪体的功能类似于哺乳动物的脂肪组织和肝脏组织，因为它储存三酰基甘油和糖原，产生脂蛋白，并作为主要的免疫部位。此外，肝细胞样卵泡细胞在营养应激时直接脂质动员和运输，合成角质层碳氢化合物，并帮助调节生育和行为。本文综述了单细胞基因组学、代谢组学和高级遗传学所带来的发现，重点关注脂肪体和衰老细胞如何将代谢与生殖、免疫和衰老结合起来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in insect science BIOLOGYECOLOGYENTOMOLOGY-ECOLOGY

CiteScore

10.40

自引率

1.90%

发文量

113

期刊介绍： Current Opinion in Insect Science is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up–to–date with the expanding volume of information published in the field of Insect Science. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following 11 areas are covered by Current Opinion in Insect Science. -Ecology -Insect genomics -Global Change Biology -Molecular Physiology (Including Immunity) -Pests and Resistance -Parasites, Parasitoids and Biological Control -Behavioural Ecology -Development and Regulation -Social Insects -Neuroscience -Vectors and Medical and Veterinary Entomology There is also a section that changes every year to reflect hot topics in the field. Section Editors, who are major authorities in their area, are appointed by the Editors of the journal. They divide their section into a number of topics, ensuring that the field is comprehensively covered and that all issues of current importance are emphasized. Section Editors commission articles from leading scientists on each topic that they have selected and the commissioned authors write short review articles in which they present recent developments in their subject, emphasizing the aspects that, in their opinion, are most important. In addition, they provide short annotations to the papers that they consider to be most interesting from all those published in their topic over the previous year.