Development of a phantom and analysis of brachytherapy dosimetry using the sulfamic acid/electron paramagnetic resonance system

IF 1.8 4区医学 Q4 ONCOLOGY

Brachytherapy Pub Date : 2026-01-01 Epub Date: 2025-11-07 DOI:10.1016/j.brachy.2025.10.002

Ghizlane Boukhris , Mohammed Mikou , Omar El Rhazouani , Redouane El Baydaoui , Sofia Jebbari , Abdeslam Bouk , Dounia Kamal

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引用次数: 0

Abstract

PURPOSE

Design and develop an epoxy resin-based cylindrical phantom to simulate cancer treatment conditions in high dose rate (HDR) brachytherapy and evaluate the spatial dose distribution around a ¹⁹²Ir source using an Sulfamic Acid/EPR system.

METHODS AND MATERIALS

A cylindrical phantom was fabricated from epoxy resin, allowing the precise insertion of a ¹⁹²Ir HDR brachytherapy source and multiple sulfamic acid dosimeters at predefined positions. The dosimetric system used in this study combined sulfamic acid detectors with EPR readout to quantify absorbed doses. Dosimeters were irradiated with doses ranging from 1 to 8 Gy, and the EPR signal intensities were measured to construct a calibration curve. Several dosimeters were then strategically positioned at various distances from the source to experimentally determine the dose distribution within the phantom.

RESULTS

The EPR dosimetry system showed a linear dose-response relationship within the 1-8 Gy range. The absorbed dose values at different locations were derived from the established calibration curve. A steep dose gradient was observed near the ¹⁹²Ir source, in agreement with theoretical expectations for HDR brachytherapy. The overall uncertainty in the dose evaluation process was estimated to be approximately 8% (k = 2).

CONCLUSIONS

This study demonstrates that the EPR/sulfamic acid dosimetry system provides a reliable and accurate method for dose evaluation in HDR brachytherapy. The developed epoxy resin phantom offers a practical and reproducible platform for experimental dose verification and quality assurance in brachytherapy treatments.

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使用胺磺酸/电子顺磁共振系统的近距离放射治疗剂量学的幻影和分析。

目的：设计和研制一种基于环氧树脂的圆柱形模体，用于模拟高剂量率（HDR）近距离治疗中的癌症治疗条件，并使用氨基磺酸/EPR系统评估192Ir源周围的空间剂量分布。方法和材料：用环氧树脂制成圆柱形模体，允许在预定位置精确插入192Ir HDR近距离治疗源和多个氨基甲酸剂量计。本研究中使用的剂量学系统结合了氨基磺酸检测器和EPR读数来量化吸收剂量。以1 ~ 8gy的剂量照射剂量计，测量EPR信号强度，建立校准曲线。然后将几个剂量计策略性地放置在离辐射源不同距离的位置，以实验方式确定模体内的剂量分布。结果：EPR剂量测定系统在1 ~ 8 Gy范围内呈线性剂量-效应关系。根据所建立的校准曲线得到不同位置的吸收剂量值。在192Ir源附近观察到一个陡峭的剂量梯度，与HDR近距离治疗的理论预期一致。剂量评估过程的总体不确定度估计约为8% （k = 2）。结论：EPR/氨基磺酸剂量测定系统为HDR近距离放射治疗的剂量评估提供了可靠、准确的方法。所开发的环氧树脂模体为近距离治疗的实验剂量验证和质量保证提供了一个实用和可复制的平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brachytherapy 医学-核医学

CiteScore

3.40

自引率

21.10%

发文量

119

审稿时长

9.1 weeks

期刊介绍： Brachytherapy is an international and multidisciplinary journal that publishes original peer-reviewed articles and selected reviews on the techniques and clinical applications of interstitial and intracavitary radiation in the management of cancers. Laboratory and experimental research relevant to clinical practice is also included. Related disciplines include medical physics, medical oncology, and radiation oncology and radiology. Brachytherapy publishes technical advances, original articles, reviews, and point/counterpoint on controversial issues. Original articles that address any aspect of brachytherapy are invited. Letters to the Editor-in-Chief are encouraged.