Bidirectional genetic overlap between mood swings and irritable bowel syndrome.

IF 1.4 4区医学 Q4 GENETICS & HEREDITY

Psychiatric Genetics Pub Date : 2025-12-01 Epub Date: 2025-11-01 DOI:10.1097/YPG.0000000000000405

Qinghua Luo, Jiawen Wang, Mingwei An, Leichang Zhang, Chen Wang

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引用次数: 0

Abstract

Background: Mood swings and irritable bowel syndrome (IBS) are closely related. However, the reason for the clinical concurrence of this phenomenon is unknown, and maybe it is because the two share genetic underpinnings.

Methods: Genome-wide association studies (GWAS) of mood swings and IBS data were used for the study. Genetic correlation was assessed using the linkage disequilibrium score regression (LDSC), genetic covariance analyzer (GNOVA), and SUPERGNOVA method. Two-sample Mendelian randomization (TwoSampleMR) was used to explore the causal relationship between the two conditions. The conditional/conjoint false discovery rate (cond/conjFDR) was used for genetic overlap analysis. Finally, LDSC applied to specific expression gene analysis was performed to identify tissues associated with the two conditions.

Results: At the genomic level, mood swings and IBS have global and local genetic correlations. Analysis of the two traits by Mendelian randomization revealed a bidirectional causal relationship. We identified 21 genetic risk loci (concFDR < 0.05) shared by mood swings and IBS, which acted in the same direction on the two traits. Additionally, mood swings and IBS shared 11 sites in the brain tissues as origins.

Conclusion: The present study suggests the existence of polygenic overlap between mood swings and IBS and provides novel insights into the genetic underpinnings and mechanisms of comorbidities occurring in these two conditions.

查看原文本刊更多论文

情绪波动和肠易激综合症之间的双向基因重叠。

背景：情绪波动与肠易激综合征（IBS）密切相关。然而，这种现象在临床上同时发生的原因尚不清楚，也许是因为两者有共同的遗传基础。方法：使用情绪波动和IBS数据的全基因组关联研究（GWAS）进行研究。采用连锁不平衡评分回归（LDSC）、遗传协方差分析仪（GNOVA）和SUPERGNOVA方法评估遗传相关性。采用双样本孟德尔随机化（TwoSampleMR）来探讨两种情况之间的因果关系。采用条件/联合错误发现率（cond/conjFDR）进行基因重叠分析。最后，应用LDSC进行特异性表达基因分析，鉴定与这两种疾病相关的组织。结果：在基因组水平上，情绪波动和IBS具有全局和局部遗传相关性。用孟德尔随机化方法对这两个性状进行分析，发现两者存在双向因果关系。结论：本研究提示情绪波动和IBS之间存在多基因重叠，并为这两种情况下发生的合并症的遗传基础和机制提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatric Genetics 医学-神经科学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.