The role of oral alpha-lipoic acid as an adjuvant antioxidant therapy in diabetic nephropathy among children and adolescents with type 1 diabetes: a randomized controlled trial

IF 3.2 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of diabetes and its complications Pub Date : 2026-01-01 Epub Date: 2025-10-18 DOI:10.1016/j.jdiacomp.2025.109201

Yasmine Ibrahim Elhenawy , Rasha Adel Thabet , Marwa G.A. Hegazy , Shymaa Ayed El-Morsy , Yasmeen AbdelAziz Fereig

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引用次数: 0

Abstract

Aim

Evaluate the oxidant-antioxidant balance and the efficacy of Alpha-lipoic acid (ALA) as an adjuvant therapy for diabetic nephropathy (DN) among individuals with type 1 diabetes (T1D).

Materials and methods

A 3 months prospective randomized controlled trial including 50 participants with DN randomly allocated (1:1) to one of two arms; an interventional arm receiving 300 mg/day of ALA (n = 25) and a non-interventional arm (n = 25). Initial assessments included HbA1c, urinary albumin excretion rate (UAER), malondialdehyde (MDA), and total antioxidant capacity (TAC). Baseline data was compared with 50 participants with T1D without DN and 50 healthy controls.

Results

T1D participants had significantly higher MDA and lower TAC levels compared to controls (P < 0.01). Within the T1D cohort, participants with DN showed significantly higher MDA and lower TAC levels (P < 0.01). MDA positively correlated with triglycerides (r = 0.53), UAER (r = 0.70), and HbA1c (r = 0.5) (p < 0.01), while TAC negatively correlated triglycerides (r = −0.41), UAER (r = −0.88), and HbA1c (r = −0.64) (p < 0.01). After 3 months of ALA supplementation, significant reductions in HbA1c, UAER, and MDA were observed, along with an increase in TAC (P < 0.01).

Conclusion

The study demonstrates that 3 months of ALA supplementation effectively reduced oxidative stress and UAER, demonstrating a potential role in protecting renal tissue from diabetes-induced oxidative damage.

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口服α -硫辛酸作为辅助抗氧化治疗1型糖尿病儿童和青少年肾病的作用：一项随机对照试验

目的：评价α -硫辛酸（ALA）作为1型糖尿病（T1D）患者辅助治疗糖尿病肾病（DN）的氧化-抗氧化平衡及疗效。材料和方法：一项为期3个月的前瞻性随机对照试验，包括50名DN患者随机分配（1:1）到两组中的一组；介入组（n = 25）和非介入组（n = 25）分别接受300 mg/天的ALA治疗。初步评估包括HbA1c、尿白蛋白排泄率（UAER）、丙二醛（MDA）和总抗氧化能力（TAC）。将基线数据与50名无DN的T1D患者和50名健康对照进行比较。结果：与对照组相比，T1D参与者的MDA水平显著升高，TAC水平显著降低(P)。结论：本研究表明，补充3个月的ALA可有效降低氧化应激和UAER，表明其在保护肾组织免受糖尿病诱导的氧化损伤方面具有潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.