Portable Low-Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Annals of Clinical and Translational Neurology Pub Date : 2026-03-08 Epub Date: 2025-11-06 DOI:10.1002/acn3.70237

Annabel Sorby-Adams, Malachi Keo, Jennifer Guo, Daire Daly, Richard Ahern, Kimon Zachary, Gregory Robbins, Rajesh T. Gandhi, Bragi Sveinsson, Adam de Havenon, Kevin N. Sheth, Otto Rapalino, Juan Eugenio Iglesias Gonzales, W. Taylor Kimberly, Shibani S. Mukerji

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引用次数: 0

Abstract

Objective

The aging population of people with HIV (PWH) raises heightened concerns regarding accelerated aging and dementia. Portable, low-field MRI (LF-MRI) is an innovative technology that could enhance access and facilitate routine monitoring of PWH. We sought to evaluate the feasibility of LF-MRI and apply a machine learning (ML) segmentation algorithm to examine atrophy and white matter hyperintensities (WMH) in PWH compared to people without HIV (PWoH) of similar age.

Methods

Individuals with a confirmed diagnosis of HIV on antiretroviral therapy underwent LF-MRI (64 mT) acquisition in the outpatient neurology clinic. PWoH with > 1 vascular comorbidity (VC cohort, n = 25) or with mild cognitive impairment (MCI cohort, n = 24) due to Alzheimer's disease served as comparators. LF-MRI brain region segmentations were derived using the ML algorithm WMH-SynthSeg in FreeSurfer. Brain regions corrected for intracranial volume were compared between cohorts after adjusting for age and sex.

Results

Thirty virally suppressed PWH were included. LF-MRI derived brain volumes from PWH demonstrated a reduction in volume of the caudate relative to PWoH with VC (p < 0.05). Volume of the putamen and white matter was reduced in PWH compared to VC (p < 0.05). Hippocampal volume was comparable between PWH and PWoH (p ≥ 0.05), while volume of the amygdala was reduced in those with MCI alone (p < 0.05). No differences in WMH were seen between these cohorts (p > 0.05).

Interpretation

LF-MRI is feasible in an outpatient setting, and ML algorithms enable detection of regional atrophy and WMH in PWH. LF-MRI may enable more frequent monitoring and earlier detection of atrophy in at-risk populations.

Abstract Image

查看原文本刊更多论文

便携式低场磁共振成像在人类免疫缺陷病毒感染者中的应用。

目的：艾滋病毒感染者（PWH）的人口老龄化引起了人们对加速衰老和痴呆的高度关注。便携式低场磁共振成像（LF-MRI）是一项创新技术，可以提高PWH的可及性并促进常规监测。我们试图评估LF-MRI的可行性，并应用机器学习（ML）分割算法来检查PWH患者与同龄非HIV患者（PWoH）的萎缩和白质高强度（WMH）。方法：在门诊神经病学诊所接受抗逆转录病毒治疗的HIV确诊患者进行LF-MRI （64 mT）采集。以患有bbb1血管合并症的PWoH （VC队列，n = 25）或因阿尔茨海默病导致轻度认知障碍的PWoH （MCI队列，n = 24）为对照。使用FreeSurfer中的ML算法WMH-SynthSeg导出LF-MRI脑区域分割。在调整了年龄和性别后，比较校正了颅内容量的脑区域。结果：包括30例病毒抑制的PWH。从PWH获得的LF-MRI脑体积显示，与VC的PWH相比，尾状核体积减少（p 0.05）。解释：LF-MRI在门诊是可行的，ML算法可以检测PWH的局部萎缩和WMH。在高危人群中，LF-MRI可以更频繁地监测和更早地发现萎缩。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)

CiteScore

9.10

自引率

1.90%

发文量

218

审稿时长

8 weeks

期刊介绍： Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.