[Research progress on the role of extracellular vesicles in the repair of skeletal muscle membrane injury].

Q3 Medicine

生理学报 Pub Date : 2025-10-25 DOI:10.13294/j.aps.2025.0005

Yi-Long Liu, Ying Wu

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引用次数: 0

Abstract

The timely and efficient repair of the plasma membrane in skeletal muscle cells following injury is critical for maintaining cellular function and tissue integrity. Extracellular vesicles (EVs) play a pivotal role in this process through multi-level mechanisms. This review systematically summarizes the generation, secretion, and multifunctional roles of EVs in the repair of skeletal muscle plasma membrane damage: (1) removing damaged membrane fragments and cellular debris via endocytosis and exocytosis to maintain plasma membrane stability; (2) fusing with the injured plasma membrane to supply essential components for membrane repair and restore membrane integrity; and (3) serving as a vital mediator of intercellular communication, transmitting repair signals, promoting intercellular interactions, and orchestrating multi-level responses to facilitate tissue regeneration and functional recovery. Additionally, this article explores the potential applications of EVs in the treatment of exercise-induced injuries and muscular diseases, aiming to provide theoretical insights and novel strategies for future research and EV-based therapeutic approaches.

查看原文本刊更多论文

[细胞外囊泡在骨骼肌膜损伤修复中的研究进展]。

骨骼肌细胞损伤后质膜的及时有效修复对维持细胞功能和组织完整性至关重要。细胞外囊泡（EVs）通过多层次的机制在这一过程中起着关键作用。本文系统综述了ev的产生、分泌及其在骨骼肌质膜损伤修复中的多功能作用：(1)通过内吞和胞吐作用清除受损的膜碎片和细胞碎片，维持质膜的稳定性；(2)与受损的质膜融合，为膜修复提供必需成分，恢复膜的完整性；(3)作为细胞间通讯的重要媒介，传递修复信号，促进细胞间相互作用，协调多层次反应，促进组织再生和功能恢复。此外，本文还探讨了电动汽车在运动损伤和肌肉疾病治疗中的潜在应用，旨在为未来的研究和基于电动汽车的治疗方法提供理论见解和新策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

生理学报 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

4820

期刊介绍： Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.