[Molecular mechanism of transcription factor PU.1 regulating erythroid differentiation and its role in hematological diseases].

Q3 Medicine

生理学报 Pub Date : 2025-10-25 DOI:10.13294/j.aps.2025.0076

Zi-Jiang Yang, Dan Hu, Xiu-Juan Zhang

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引用次数: 0

Abstract

Transcription factor PU.1, as a core member of the ETS family, plays a pivotal role in the multi-lineage differentiation of hematopoietic stem cells, particularly in the regulation of erythroid differentiation. PU.1 orchestrates the process of hematopoietic stem cell differentiation towards erythroid cells by modulating the transcription of lineage-determining factors and interacting with other key transcription factors in a fine-tuned manner. PU.1 plays an irreplaceable role in the development and function of red blood cells, with its abnormal expression closely related to the occurrence and progression of various blood diseases, including leukemia, myelodysplastic syndromes, and various types of anemia. This article comprehensively analyzes the functional roles and molecular mechanisms of PU.1 in various stages of erythroid differentiation, as well as its potential roles in related blood diseases. This review not only deepens our understanding of the mechanism by which PU.1 regulates erythroid differentiation, but also provides theoretical grounds for blood disease therapies based on PU.1.

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[转录因子PU.1调控红细胞分化的分子机制及其在血液病中的作用]。

转录因子PU.1作为ETS家族的核心成员，在造血干细胞的多系分化中起着举足轻重的作用，尤其是在红血系分化的调控中。PU.1通过调节谱系决定因子的转录和与其他关键转录因子的相互作用，以精细的方式协调造血干细胞向红系细胞分化的过程。PU.1在红细胞的发育和功能中具有不可替代的作用，其异常表达与白血病、骨髓增生异常综合征、各种类型的贫血等多种血液病的发生和进展密切相关。本文全面分析了PU.1在红细胞分化各阶段的功能作用、分子机制及其在相关血液病中的潜在作用。这一综述不仅加深了我们对PU.1调控红细胞分化机制的认识，也为基于PU.1的血液病治疗提供了理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

生理学报 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

4820

期刊介绍： Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.