Adherence with hormonal therapy in women with breast cancer: a cross-sectional study in Medellin, Colombia.

IF 1.4 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Colombia Medica Pub Date : 2025-06-30 eCollection Date: 2025-04-01 DOI:10.25100/cm.v56i2.6613

Katerin Puerta Alzate, Camila Lema Calidonio, Mauricio Lema Medina, Paula Villa García

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Abstract

Background: Although hormone therapy is a cornerstone in the treatment of breast cancer, low therapeutic adherence is commonly reported, and there is limited evidence on the predictors that contributes to improving adherence in this population.

Objective: To identify factors associated with adherence to hormone therapy in women with breast cancer, in an oncology clinic in Medellín-Colombia (2019- 2023).

Methods: Cross-sectional analytical study. Women >18 years old with hormone receptor-positive breast cancer who were undergoing hormone therapy were included. The MMAS-8 scale was used to measure and classify therapeutic adherence into three levels: low, medium, and high. Data was analyzed by multinomial logistic regression.

Results: One hundred seventy-eight patients with a median age of 64.0 years were included. 50.0% were treated with tamoxifen. The prevalence of non-adherence was 48.9%. 70.2% had adverse effects of hormone therapy, and forgetfulness was the main reason for discontinuation (76.19%). Age was associated with therapeutic adherence, with older women being the most adherent (83.5%). Women with adverse effects, stage III-IV, low socioeconomic and educational level, and a lack of support network had lower therapeutic adherence.

Conclusions: A high prevalence of moderate and low therapeutic adherence is demonstrated in younger women from lower socioeconomic and educational backgrounds. Preventive strategies are needed to mitigate factors that negatively influence therapeutic adherence.

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乳腺癌患者坚持激素治疗：哥伦比亚麦德林的一项横断面研究

背景：虽然激素治疗是乳腺癌治疗的基石，但通常报道的治疗依从性较低，而且在这一人群中，有助于提高依从性的预测因素的证据有限。目的：在Medellín-Colombia（2019- 2023）的肿瘤诊所中，确定与乳腺癌患者坚持激素治疗相关的因素。方法：横断面分析研究。年龄在18岁左右的激素受体阳性乳腺癌患者正在接受激素治疗。MMAS-8量表用于测量治疗依从性并将其分为低、中、高三个级别。数据采用多项逻辑回归分析。结果：纳入178例患者，中位年龄64.0岁。50.0%的患者给予他莫昔芬治疗。不依从率为48.9%。70.2%的患者出现激素治疗不良反应，其中健忘是导致患者停药的主要原因（76.19%）。年龄与治疗依从性有关，老年妇女最坚持治疗（83.5%）。不良反应、III-IV期、低社会经济和教育水平、缺乏支持网络的妇女治疗依从性较低。结论：在社会经济和教育背景较低的年轻女性中，中等和低治疗依从性的患病率较高。需要采取预防策略来减轻对治疗依从性产生负面影响的因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colombia Medica MEDICINE, GENERAL & INTERNAL-

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Colombia Médica is an international peer-reviewed medical journal that will consider any original contribution that advances or illuminates medical science or practice, or that educates to the journal''s’ readers.The journal is owned by a non-profit organization, Universidad del Valle, and serves the scientific community strictly following the International Committee of Medical Journal Editors (ICMJE) and the World Association of Medical Editors (WAME) recommendations of policies on publication ethics policies for medical journals. Colombia Médica publishes original research articles, viewpoints and reviews in all areas of medical science and clinical practice. However, Colombia Médica gives the highest priority to papers on general and internal medicine, public health and primary health care.